Phytochemicals as Lead Compounds for New Drug Discovery
Coordonnateurs : Egbuna Chukwuebuka, Kumar Shashank, Ifemeje Jonathan C., Ezzat Shahira M., Kaliyaperumal Saravanan
Phytochemicals as Lead Compounds for New DrugDiscovery presents complete coverage of the recent advances in the discovery of phytochemicals from medicinal plants as models to the development of new drugs and chemical entities. Functional bioactive compounds of plant origin have been an invaluable source for many human therapeutic drugs and have played a major role in the treatment of diseases around the world. These compounds possess enormous structural and chemical diversity and have led to many important discoveries. This book presents fundament concepts and factors affecting the choice for plant-based products, as well as recent advances in computer-aided drug discovery and FDA drug candidacy acceptance criteria. It also details the various bioactive lead compounds and molecular targets for a range of life-threatening diseases including cancer, diabetes, and neurodegenerative diseases.
Written by a global team of experts, Phytochemicals as Lead Compounds for New Drug Discovery is an ideal resource for drug developers, phytochemists, plant biochemists, food and medicinal chemists, nutritionists and toxicologists, chemical ecologists, taxonomists, analytical chemists, and other researchers in those fields. It will also be very valuable to professors, students, and researchers in this domain.
Part I: Plants As Natural Sources Of Drugs 1. Plant Secondary Metabolites as Lead Compounds for the Production of Potent Drugs 2. Factors Affecting the Choice for Plant-based Products in Drug Discoveries 3. Advances in Computer-Aided Drug Discovery 4. FDA drug candidacy acceptance criteria and steps: Problems and way forward
Part II: Bio-functional Leads for Drug Development 5. Bioactive lead compounds and molecular targets for the treatment of heart diseases 6. Natural bioactive lead compounds effective against haematological malignancies 7. Adjunct Therapeutic Potential of Phytochemicals Against Cancer 8. Anti-diabetic lead compounds and targets for drug development 9. Anti-obesity functional leads and targets for drug development 10. Phytochemicals as therapeutic interventions in neurodegenerative diseases 11. Organosulfur phytochemicals against metabolic and neurodegenerative diseases: Benefits and risks 12. Lead compounds with the potentials for the treatment of chronic liver diseases 13. Phytocompounds and potential target sites against skin diseases 14. Phytochemicals as emerging therapeutic agents for alopecia treatment 15. Antiviral phytocompounds for drug development: A data mining studies 16. Shikimic acid as intermediary model for the production of drugs effective against influenza virus 17. Antimicrobial Lead Compounds from Marine Plants 18. Antibacterial lead compounds and targets for drug development 19. Awareness and Current Therapeutic Strategies of Malaria 20. Bioactive lead compounds and targets for the development of anti-malarial drugs 21. Bioactive lead compounds and targets for the development of anti-inflammatory drugs 22. Functional lead compounds and targets for the development of drugs for the treatment of male infertility 23. Prenylated flavonoids as a promising drug discovery candidate: A pharmacological update
Researchers working in drug development, phytochemists, plant biochemists, food and medicinal chemists, nutritionists, toxicologists, chemical ecologists, taxonomists, and analytical chemists
Chukwuebuka Egbuna (PhD) is a chartered chemist and academic researcher. He is a member of the Institute of Chartered Chemists of Nigeria (ICCON), the Nigerian Society of Biochemistry and Molecular Biology (NSBMB), and the Royal Society of Chemistry (RSC) (United Kingdom). Dr. Egbuna is the founder and editor of the Elsevier book series on Drug Discovery Update. The series includes books, monographs, and edited collections from all areas of drug discovery including emerging therapeutic claims for the treatment of diseases. He has published research articles in many international journals of repute and is ranked among the top 500 Nigerian scientists in SciVal/SCOPUS. He has edited more than 25 books with Elsevier, Springer, Wiley, and Taylor & Francis. His most recent book is the three volume Coronavirus Drug Discovery, published by Elsevier. Dr. Egbuna is the founder and the publishing director of IPS Intelligentsia Publishing Services.
Shashank Kumar, PhD, obtained his BSc, MSc, and PhD degrees in biochemistry from the University of Allahabad. He has worked as a postdoctoral fellow at the Department of Biochemistry in King George’s Medical University. Dr. Kumar has about 60 published scientific papers, reviews, editorial articles, and book chapters in various national and international peer-reviewed journals and has been cited more than 1,200 times. His expertise is in the areas of free radical biology, cancer biology, characterization of plant products, xenobiotic metabolism, and microbiology. He is familiar with many biochemical techniques such as spectrophotometry, ELISA, electrophoresis, PCR, RT-PCR, flow cytometry, TLC, HPLC, LC-MS, cell culture, and microbiological techniques. He has presented his research findings at more than 25 national and international conferences and has attended about 30 workshops at many major universities and medical colleges throughout the India. Dr. Kumar is a life-time member of the Italo-Latin American Society
- Presents fundamental concepts and factors affecting choice for plant-based products
- Details the FDA drug candidacy acceptance criteria, including bottlenecks and way forward
- Highlights recent advances in computational-based drug discovery
- Focuses on the discovery of new drugs and potential druggable targets for the treatment of chronic diseases of world importance
Date de parution : 09-2019
Ouvrage de 378 p.
21.4x27.6 cm
