Self-organization in Chemical and Biochemical Systems

This book presents theoretical and experimental methods and describes their application for the analysis of real experimental systems and kinetic models. It describes how complex features of biochemical systems arise from underlying molecular interactions, tools available for their quantitative characterization, the functional role of dynamics, and how scientists can use self-organization to their advantage.

What is self-organization and how can it arise?. Basic concepts. Feedback mechanisms. Stability of non-equilibrium stationary states and dynamic transitions. Model normalization and derivation of dimensionless variables. The thermokinetic oscillator. Stochastic analysis. Stoichiometric Network Analysis. Quenching of small limit-cycle oscillations. The Bray-Liebhafsky oscillating reaction. The Belousov-Zhabotinsky oscillating reaction. The Briggs-Rauscher oscillating reaction. Modeling glycolysis. Modeling the HPA axis dynamics. Analytical applications.