Handheld Total Chemical and Biological Analysis Systems, 1st ed. 2018 Bridging NMR, Digital Microfluidics, and Semiconductors

The book Handheld Total Chemical and Biological Analysis Systems: Bridging NMR, Digital Microfluidics, and Semiconductors centers on the complete design of Nuclear Magnetic Resonance (NMR) microsystems for in vitro chemical and biological assays based on semiconductor chips and portable magnet. Different sensing mechanisms for CMOS in vitro assay are compared, key design criteria of the CMOS transceiver for NMR measurement are revealed, and system-level optimizations of the CMOS NMR platform utilizing digital microfluidic and diverse functions of the CMOS technology are discussed. Two CMOS NMR platforms are implemented, each of these focuses on different aspect of optimization.

Introduction.- State-of-the-Art CMOS In Vitro Diagnostic Devices.- Electronic-Automated Micro-NMR Assay with DMF Device.- One-Chip Micro-NMR Platform with B0-field Stabilization.- Conclusion and Outlook.- Appendix.- Index.

Ka-Meng Lei (S’12-M’17) received the B.Sc. degree in electrical and electronics engineering, and graduated from Honours College from University of Macau (UM), Macao in 2012. He completed his Ph.D. degree in the State-Key Laboratory of Analog and Mixed-Signal VLSI (SKL-AMSV) and Faculty of Science and Technology – ECE, UM in 2016. He is currently working as a lecturer in the same laboratory under the “Macao Fellow” program at UM. Since Jun. 2017, he has been a postdoctoral fellow (visiting) at Harvard University, John A. Paulson School of Engineering and Applied Sciences.

Dr. Lei worked as a trainee at Evatronix IP, Gliwice, Poland in the summer of 2012. He was a research assistant in SKL-AMSV to work on CMOS micro-NMR biosensor, and will continue the development of it with the Harvard University.

He has published 13 referred papers (6 in scientific journals & 7 in conference proceedings) as well as 2 US patents. His research interests include sensors and analog front-end interfaces, analog circuit techniques for micro-NMR, intelligent digital microfluidics platform, and multidisciplinary design of biomedical devices.

Dr. Lei (co-)received the Chipidea Microelectronics Prize (Bachelor level) 2012; Best Paper Award in Asia Symposium on Quality Electronic Design 2013; Student/Young Researcher Grant from The Chemical and Biological Microsystems Society 2015; Distinguished Design Award of the Student Design Contest in IEEE Asian Solid-State Circuits Conference 2015; Silkroad Award in IEEE International Solid-State Circuits Conference 2016; and the IEEE Solid-State Society Predoctoral Achievement Award in 2017.

Pui-In Mak (Elvis) (S’00-M’08-SM’11) received the B.Sc. (’03) and Ph.D. (’06) degrees from the University of Macau (UM), where he is currently Full Professor at the Faculty of Science and Technology - ECE; Associate Director (Research) an