Hypofractionated and Stereotactic Radiation Therapy (2^nd Ed., 2nd ed. 2024) A Practical Guide

This new edition summarizes the data and techniques for hypofractionation and stereotactic radiation in a clinically-accessible way. Hypofractionated radiation therapy, which consists of larger-dose radiation treatments that are given over a shorter time period compared to conventional radiation fraction sizes, is used to treat a variety of cancers, including prostate, breast, lung, and colorectal. Conventional radiation therapy and hypofractionated radiation therapy often have different effectiveness rates for cancer treatment and have different impacts on normal tissues in terms of causing toxicity. There is a significant and continually evolving body of literature on the use of different dosing regimens to treat a variety of cancers, and radiation oncologists need to keep up with the various dosing schedules, the effect of each regimen on cancer control in different cancers, and how the different schedules affect each organ in terms of toxicity.

This book provides concise, up-to-date information ranging from commonly-used dose-fractionation schemes for hypofractionated and stereotactic body radiotherapy to simulation and treatment specifications to published safety and efficacy data. Chapters additionally examine the biological rationales for the efficacy of hypofractionated radiation; present clinical studies that demonstrate the efficacy and safety of hypofractionated radiation treatment in a variety of cancers; and describe the advances in technology that have allowed hypofractionated radiation to be safely given. All chapters are fully revised with the latest treatments and updated effectiveness and toxicity of previously discussed treatments, all based on recent clinical trials and large analytical studies.

This is an ideal guide for radiation oncology clinicians and trainees. 

The History and Radiobiology of Hypofractionation.- The Physics of Hypofractionation and SRS/SBRT.- Part I Benign Central Nervous System Tumors.- Arteriovenous Malformation.- Trigeminal Neuralgia.- Meningioma.- Vestibular Schwannoma.- Pituitary Adenoma.- Part II Malignant Central Nervous System Tumors.- Glioblastoma.- Secondary Malignant (Metastases).- Part III Head and Neck Tumors.- Nasopharynx.- Larynx.- Other Head and Neck Sites.- Intraoral Cone (IOC).- Brachytherapy.- Intraoperative Radiotherapy (IORT).- Re-irradiation.- Part IV Skin.- Skin (Melanoma and Nonmelanoma Skin Cancers).- Part V Lung Tumors.- Hypofractionation for Lung Tumors (Primary Malignant, Secondary Malignant).- Part VI Breast Cancer.- Breast Cancer.- Part VII Gastrointestinal Cancer.- Hepatobiliary Malignancies.- Pancreas Cancer.- Rectal Cancer.- Part VIII Genitourinary Cancer.- Prostate Cancer Hypofractionation.- Kidney Cancer.- Part IX Spine Tumors and Non-Spine Bone Metastases.- Spine Tumors and Non-Spine Bone Metastases.- Part X Gynecologic Malignancies.- Uterine Cervix Cancer.- Endometrial Cancer.

Fully updated and easily accessible guide to published data on efficacy of different dose fractionations Includes fully revised chapters with the latest treatments Presents biological rationale and clinical data for use of hypofractionated radiation therapy in cancer treatment