Nasopharyngeal Carcinoma From Etiology to Clinical Practice

Langue : Anglais

Coordonnateurs : Lee Anne W.M., Lung Maria Li, Ng Wai Tong

Couverture de l’ouvrage Nasopharyngeal Carcinoma

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Nasopharyngeal Carcinoma: From Etiology to Clinical Practice discusses NPC from basic science, to clinical management through the perspective of members of the Centre for Nasopharyngeal Carcinoma Research in Hong Kong. It encompasses not only the most detailed information about multiple aspects of NPC, but also the modern day research model of scientist-clinician collaboration, focusing on bench-to-bedside approach. Basic science is covered, discussing genetics and genomics in NPC and its epidemiology and the role of Epstein-Barr Virus (EBV). Translational research is also covered, presenting topics such as animal models, plasma EBV DNA, molecular imaging and immunotherapy, amongst other topics.

This book is a valuable source for cancer researchers, oncologists, medical oncologists and several members of the biomedical field who are interested in learning more about NPC management from both clinical and research perspectives.

1. Nasopharyngeal carcinoma: A history2. NPC genetics and genomics3. Pathogenesis of nasopharyngeal carcinoma: histogenesis, EBV infection and tumour microenvironment4. Epidemiology and population screening5. Establishment of NPC cell line, patient-derived xenografts (PDXs) and immortalized nasopharyngeal epithelial cells for NPC and EBV infection study6. Translational studies: Drug candidates and preclinical testing7. Conventional and novel diagnostic biomarkers and approaches for detection of nasopharyngeal carcinoma 8. Imaging of nasopharyngeal carcinoma9. Staging of nasopharyngeal carcinoma based on 8th edition of the AJCC/UICC staging system 10. Standard of care for NPC (2018-2020)11. International consensus on delineation of target volumes and organs at risk12. Advances in radiotherapy13. Salvage of local recurrence14. Management of metastatic nasopharyngeal carcinoma 15. Cancer immunotherapy for nasopharyngeal carcinoma16. Concluding chapter: Nasopharyngeal carcinoma – basic science17. Concluding chapter: Nasopharyngeal cancer – clinical aspects

graduate students on cancer, cancer researchers, clinicians, oncologists

Prof. Lee is currently the Clinical Professor and Head of the Department of Clinical Oncology, The University of Hong Kong, and she is also the Chief of Service for the Center of Clinical Oncology at The University of Hong Kong-Shenzhen Hospital. She serves in many international academic organizations, including being the Board of Directors for the Union for International Cancer Control (UICC) and the Coordinator of the Global Advisory Group for UICC, as well as the Vice-Chairman of the National Cancer Staging Committee of China. She has extensive publications in leading scientific journals focusing on various aspects of NPC research. She is also the recipient of many awards and honours from all over the world for her contributions to cancer research including the Sir Patrick Manson Gold Medal by The University of Hong Kong; Gilbert Fletcher Distinguished Professor Lecturer by The University of Texas, M.D. Anderson Cancer Center; Honorary Membership by the European Society of Therapeutic Radiology and Oncology (ESTRO); Honorary Membership by the Radiological Society of North America (RSNA); and Wharton Lecturer by The University of Toronto, Princess Margaret Hospital, Canada.
Prof. Lung is currently the Chair Professor in the Department of Clinical Oncology, The University of Hong Kong. She is also the Director of the Area of Excellence Center for Nasopharyngeal Carcinoma (NPC) Research and the Laboratory of Cancer Molecular Genomics. She has been studying the contributions of host genetics and Epstein-Barr Virus (EBV) infection to the development of the cancer. She published extensively on EBV genotypes associated with NPC. Her early studies on the molecular genetic basis of NPC utilized functional approaches to complement defects in NPC cell lines, resulting in identification of critical regions and then candidate tumor suppressor genes contributing to the development of these tumors. More recently, using next-generation sequencing (NGS) approaches, she has co

Written by members of the Centre for Nasopharyngeal Carcinoma Research
Extensively covers various aspects of NPC, including basic science and the clinical advances of both scientists and clinicians
Discusses the molecular information gained through laboratory studies to stimulate research on new treatment strategies