Pharmacology and Pharmacotherapeutics, 26e (26^th Ed.)

This book strengthens the scientific knowledge base and promotes rational thinking among students

The Medical Council of India (MCI) has introduced a competency-based curriculum in 2019, which not only lays emphasis on integration with clinical and pre-clinical subjects but also clearly states subject competencies and defines domains and levels to be achieved for each of them. In addition, it is clinically oriented and gives due importance to the self-directed learning. The duration of teaching for the subject of Pharmacology in the new curriculum has been reduced to one year with additional dedicated time to revisit it in the subsequent years. This 26th edition of Pharmacology and Pharmacotherapeutics has been revised considerably to match the demands of the new curriculum.

Right from its conception, this book has used an integrated approach intertwining current knowledge of pathophysiology of the disease, pharmacology of available drugs and strategies for medical management of diseases. We have made every attempt to provide up-to-date information about the drugs while focussing on the aspects relevant to their use in clinical practice.

• Structured pedagogy facilitating feature-rich presentation and organization of the content, which makes it more student friendly
• Richly illustrated content supplemented with large number of tables and boxes - explaining physiology, complex concepts, relevant drug features and principles of pharmacotherapy
• Mechanisms of drug actions, explained in text and illustrated via diagrams as well as videos (animations) for better understanding and retention
• Key points in pharmacology and pharmacotherapy of diseases highlighted throughout the book
• Practical tips in this book serve as a reference guide in practice so that students can treat their patients effectively and confidently

• Thoroughly revised content, fully in line with the New CBME Curriculum

• Knowledge-related competencies labelled within the text
• Drug information fully updated, presented in crisp and integrated manner
• Illustrations increased, converted to multicolour graphics
• Core points and therapeutics highlighted with coloured backgrounds in the text
• Widely reviewed and updated text, in line with feedback from faculty members and students
• Over 100 flow charts of drug classification added, available as a separate section within the book

Important Additions/Updations

• Management of ADRs and drug interactions
• Epilepsy management - updated
• Psycopharmacology - clinically oriented
• Prostaglandin uses - at a glance
• Updated treatment guidelines for asthma and COPD
• Newer antimicrobials, beta lactamase inhibitors and antibiotic stewardship programme
• Current guidelines for TB management
• STD prophylaxis
• Drug therapy of HBV, HCV and coronaviruses
• Metronomic chemotherapy
• Recent trends in management of diabetes mellitus
• Immunopharmacology - simplified

SECTION 1: General Pharmacology

1. General Considerations and Pharmacokinetics

2. Pharmacodynamics - Drug Receptor Interactions; Adverse Drug Reactions

3. Principles of Drug Prescribing; Factors Modifying the Effects of a Drug; and Drug

Interactions

4. Drug Invention, New Drug Development, and Drug Assay

5. General Considerations

6. Aliphatic Alcohols

7. General Anaesthetics

8. Sedatives, Hypnotics and Pharmacotherapy of Sleep Disorders

9. Drugs Effective in Seizure Disorders

10. Opioid Analgesics and Antagonists

11. Analgesic-Antipyretics and Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)

12. Central Nervous System Stimulants, 174

13. Psychopharmacology - 1: Introduction, Antipsychotic Drugs, Pharmacotherapy of Psychosis and Psychotogenic Drugs

14. Psychopharmacology - 2: Anxiolytics, Antidepressants and Pharmacotherapy of Depression and Manic-Depressive Psychosis

15. Drug Therapy of Parkinsonism and Other Neurodegenerative Disorders

16. Cocaine, Procaine and Other Synthetic Local Anaesthetics

17. General Considerations

18. Adrenergic Agonists and Antagonists

19. Cholinergic Drugs

20. Muscarinic Receptor Blocking Drugs; Pharmacotherapy of Bladder Dysfunction

21. Ganglion Stimulating and Blocking Drugs; Treatment of Tobacco Dependence

22. Skeletal Muscle Relaxants

SECTION 5: Other Biogenic Amines and Polypeptides

23. Histamine and Antihistaminic Drugs

24. 5-Hydroxytryptamine (Serotonin), Its Agonists and Antagonists; and Treatment of Migraine

25. Angiotensin, Kinins, Leukotrienes, Prostaglandins and Cytokines

26. Pharmacotherapy of Cough

27. Pharmacotherapy of Bronchial Asthma, COPD and Rhinitis

28. Pharmacotherapy of Cardiac Arrhythmias

29. Pharmacotherapy of Angina Pectoris, Acute MI and Peripheral Vascular Diseases

30. Pharmacotherapy of Hypertension, Pulmonary Hypertension and Orthostatic Hypotension

31. Pharmacotherapy of Heart Failure

32. Pharmacotherapy of Shock

33. Drugs and Blood Coagulation

34. Drugs Effective in Iron Deficiency and Other Related Anaemias

35. Drugs Effective in Megaloblastic Anaemias, Neutropenia and Thrombocytopenia

36. Drug-Induced Blood Dyscrasias

37. Diuretic and Antidiuretic Drugs, and Drug-Induced Nephrotoxicity

38. Appetite Stimulants, Digestants, Antiflatulents, Appetite Suppressants and Hypolipidaemic

Agents

39. Emetics, Drug Therapy of Vomiting, Vertigo and Diarrhoea

40. Pharmacotherapy of Constipation

41. Pharmacotherapy of Peptic Ulcer Disease

42. Pharmacology of Ergot Alkaloids, Oxytocin, Other Oxytocics and Uterine Relaxants

43. Sulphonamides, Trimethoprim, Cotrimoxazole, Nitrofurans and Quinolones

44. Penicillins and Other Antibiotics Effective Mainly against Gram-Positive Organisms

45. Aminoglycosides and Other Antibiotics Effective Mainly Against Gram-Negative Organisms

46. Antibiotics Effective Against Both Gram-Positive and Gram-Negative Organisms

47. Tetracyclines and Chloramphenicol

48. Antifungal Agents

49. General Principles of Chemotherapy of Infections

50. Chemotherapy of Urinary Tract Infections

51. Chemotherapy of Sexually Transmitted Diseases

52. Chemotherapy of Tuberculosis

53. Chemotherapy of Leprosy

54. Chemotherapy of Malaria

55. Chemotherapy of Amoebiasis

56. Chemotherapy of Other Protozoal Infections

57. Chemotherapy of Viral Infections

58. Chemotherapy of Helminthiases

59. Chemotherapy of Malignancy

60. Antiseptics, Disinfectants and Insecticides

61. Anterior Pituitary Hormones

62. Thyroid Hormones and Antithyroid Drugs

63. Pancreatic Hormones, Antidiabetic Drugs and Pharmacotherapy of Diabetes Mellitus

64. Adrenal Cortical Steroids

65. Gonadotropins, Estrogens and Progestins

66. Antifertility Agents and Ovulation-Inducing Drugs

67. Androgens, Anabolic Steroids, Antiandrogens and Treatment of Sexual Dysfunction

68. Calcium, Phosphorus, Fluoride and Magnesium Metabolism; Parathyroid Hormone and

Vitamin D; Treatment of Osteoporosis

69. Pharmacotherapy of Common Skin Disorders and Skin Protectives

70. Ocular Pharmacology

71. General Considerations: Vaccines and Antisera

72. Immunoglobulins, Monoclonal Antibodies, Immunosuppressants and Immunomodulators

73. Pharmacotherapy of Gout, Rheumatoid Arthritis and Osteoarthritis

74. Metals and Their Antagonists

75. Gases: Therapeutic and Toxic

76. Enzymes in Therapy

77. Vitamins and Antioxidants

78. Drugs, Pregnancy and the Infant

Appendix

Illustration Credits

Index

Seth GS Medical College and KEM Hospital, Parel , Mumbai - 400 012