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The MAK collection for occupational health & safety. Part IV : Biomonitoring methods, Volume 11

Langue : Anglais

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Couverture de l’ouvrage The MAK collection for occupational health & safety. Part IV : Biomonitoring methods, Volume 11
Detailed, ready-to-use protocols for human biomonitoring methods, are provided here, which were developed to monitor concentrations of occupational toxicants, yet can be equally used for environmental monitoring. Examples are new methods for the determination of organophosphates or musk compounds in blood. All the methods are reliable, reproducible, adhere to 'Good Laboratory Practice' standards and cover all the required steps from sampling to the interpretation of results with respect to relevant biological exposure values. This includes data on precision, accuracy, and detection limit, calibration procedures as well as potential sources of systematic errors.
Contents of Volumes 1 11.

Working Group Analytical Chemistry of the Commission of the Deutsche Forschungsgemeinschaft for the Investigation of Health Hazards of Chemical Compounds in the Work Area.

Organization Objectives and operational procedure Development, examination, release and quality of the analytical methods Publications of the working group Withdrawal of methods.

Terms and symbols used.

Terminology symbols.

Preliminary Remarks.

The use of liquid chromatography/mass spectrometry (LC/MS) in biological monitoring.

Methods.

Bisphenol A in urine.

Di(2 ethylhexyl) phthalate (DEHP) metabolites (2 ethyl 5 hydroxyhexyl phthalate, 2 ethyl 5 oxohexyl phthalate, mono(2 ethylhexyl) phthalate) in urine.

5 Hydroxy N methyl 2 pyrrolidone (5 HNMP) and 2 hydroxy N methylsuccinimide (2 HMSI) in urine as metabolites of N methyl 2 pyrrolidone (NMP).

Iridium in urine, addendum to "platinum and gold".

Monohydroxybutenylmercapturic acid (MHBMA) and dihydroxybutylmercapturic acid (DHBMA) in urine as metabolites of 1,3 butadiene.

Neuropathy target esterase (NTE) in leukocytes.

Organophosphates (chlorpyrifos, diazinon, fenitrothion, fenthion, malathion) in whole blood.

Palladium in urine.

Polycyclic musk compounds (PMC) in blood (1,3,4,6,7,8 hexahydro 4,6,6,7,8,8 hexamethy lcyclopenta[g] 2 benzopyrane (HHCB), 7 acetyl 1,1,3,4,4,6 hexamethyltetrahydro naphthalene (AHTN), 4 acetyl 1,1 dimethyl 6 tert butylindane (ADBI) and 6 acetyl 1,1,2,3,3,5 hexamethylindane (AHDI)).

Propylene and diethylene glycol ethers in urine and blood (1 butoxypropanol 2, diethylene glycol dibutyl ether, diethylene glycol diethyl ether, diethylene glycol dimethyl ether, diethylene glycol monobutyl ether, diethylene glycol monobutyl ether actetate, diethylene glycol monoethyl ether, diethylene glycol monoethyl ether acetate, diethylene glycol monomethyl ether, dipropylene glycol monomethyl ether, 1 ethoxypropanol 2, 3 ethoxypropanol 1, 1 ethoxypropyl acetate 2, 1 methoxypropanol 2, 1 methoxypropanone 2, 1 methoxypropyl acetate 2, propylene glycol diacetate).

2,3,7,8 Tetrachlorodibenzo p dioxin in blood.

Members and Guests of the Working Subgroup Analyses of Hazardous Substances in Biological Materials of the Commission of the Deutsche Forschungsgemeinschaft for the Investigation of Health Hazards of Chemical Compounds in the Work Area.

Substance.

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