Smad Signal Transduction, Softcover reprint of hardcover 1st ed. 2006 Smads in Proliferation, Differentiation and Disease Proteins and Cell Regulation Series, Vol. 5
For the first time world-leading experts in the area of cellular signaling have joined to the production of a book on Smad signal transduction. Smads are the principal intracellular effectors of TGF-b family members that control numerous cellular responses with critical roles in development and in tissue homeostasis. In a series of 22 cutting-edge chapters forward looking reviews of Smads are provided that cover their discovery, evolution, role in development, mechanism of action and regulation, and how deregulation in Smad signalling contributes to human diseases. Written for an audience with basic understanding of molecular and cell biology, this volume provides an in-depth review of a rapidly developing field and extensive cross-references between chapters are provided. This book will be of particular interest to basic and applied biomedical researchers (students, post-docs or group leaders) with desire to understand the principles of cell-cell communication and mechanisms by which signaling pathways and gene programs control cell proliferation and differentiation, and how this knowledge may come to be applied in the clinic.
Date de parution : 11-2010
Ouvrage de 472 p.
16x24 cm
Date de parution : 08-2006
Ouvrage de 472 p.
15.5x23.5 cm
Thèmes de Smad Signal Transduction :
Mots-clés :
evolution; gene expression; genes; molecular evolution; proteins; regulation; signal transduction; transcription