Translational Regulation of Gene Expression 2, Softcover reprint of the original 1st ed. 1993

This book, which results from the dramatic increase in interest in the control mechanism employed in gene expression and the importance of the regulated proteins, presents new information not covered in Translational Regulation of Gene Expression, which was published in 1987. It is not a revision of the earlier book but, rather, an extension of that volume witl, special emphasis on mecha­ nIsm. As the reader will discover, there is enormous diversity in the systems employing genes for translational regulation in order to regulate the appearance of the final product-the protein. Thus, we find that important proteins such as protooncogenes, growth factors, stress proteins, cytokines, lymphokines, iron­ storage and iron-uptake proteins, and a panorama of prokaryotic proteins, as well as eukaryotic viral proteins, are translationally regulated. Since for some gene products the degree of control is greater by a few orders of magnitude than their transcription, we can state that for these genes, at least, the expression is translationall y controlled. Translational regulation of gene expression in eukaryotes has emerged in the last few years as a major research field. The present book describes mechanisms of translational regulation in bacteria, yeast, and eukaryotic viruses, as well as in eukaryotic genes. In this book we try to provide in-depth coverage by including important examples from each group rather than systematically including all additional systems not described in the previous volume.

1 A Two-Ribosome Model for Attenuation.- 2 Regulation of Ribosomal Protein mRNA Translation in Bacteria: The Case of S.- 3 Role of Elongation Factors in Steering the Ribosomal Elongation Cycle.- 4 Genetics of Translation Initiation Factors in Saccharomyces cerevisiae.- 5 Regulation of GCN4 Expression in Yeast: Gene-Specific Translational Control by Phosphorylation of eIF-2?.- 6 Co- and Posttranslational Processes and Mitochondrial Import of Yeast Cytochrome c.- 7 eIF-4E Phosphorylation and the Regulation of Protein Synthesis.- 8 Interferon-Induced and Double-Stranded RNA-Activated Proteins as Key Enzymes Regulating Protein Synthesis.- 9 Translational Regulation by Vaccinia Virus.- 10 Translational Control by Adenovirus-Associated RNA.- 11 Translational Regulation in Adenovirus-Infected Cells.- 12 Concerted Gene Expressions in Elicited Fibroin Synthesis.- 13 Translational Control in the Circadian Regulation of Luminescence in the Unicellular Dinoflagellate Gonyaulax polyedra.- 14 Autoregulation of the Heat-Shock Response.- 15 Repressor-Mediated Translational Control: The Regulation of Ferritin Synthesis by Iron.- 16 Control of Ribosomal Protein Synthesis in Eukaryotic Cells.- 17 Translational Regulation in Reticulocytes: The Role of Heme-Regulated eIF-2? Kinase.- 18 Regulation of Reticulocyte eIF-2? Kinases by Phosphorylation.- 19 Initiation Mechanisms Used in the Translation of Bicistronic mRNAs.- 20 Protein Synthesis Initiation in Animal Cells: Mechanism of Ternary and Met-tRNAf•40S•mRNA Complex Formation and the Regulatory Role of an eIF-2-Associated 67-kDa Polypeptide.- 21 Phosphorylation of Elongation Factor 2: A Mechanism to Shut Off Protein Synthesis for Reprogramming Gene Expression.- 22 A Coupled Translation-Transcription Cell-Free System.