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Vascularization for Tissue Engineering and Regenerative Medicine, 1st ed. 2021 Tissue Engineering and Regeneration Series

Langue : Anglais
Couverture de l’ouvrage Vascularization for Tissue Engineering and Regenerative Medicine
This reference work presents the basic principles of angiogenesis induction, including the roles of signaling factors such as hypoxia-inducible factors, biophysical stimulation and angiogenic cells. The book also covers lymphogenesis induction. Both the established fundamentals in the field as well as new trends in the vascularization of engineered tissues are discussed. These include pre-vascularization strategies using preparation of channeled scaffolds and preparation of decellularized blood vessel trees, approaches to inducing formation of microvasculature and approaches to inducing the growth of vascular networks. The authors expand on these concepts with current studies of dual-level approaches to engineer vascularized tissue composites. The book concludes with a discussion of current clinical approaches and the use of vascular grafts in the context of providing clinical practice with new tissue engineering strategies.
Angiogenesis induction.- Physical stimulation.- Shockwave.- HIF stabilisation.- Angiogenic factors.- Slow release.- Angiogenic cells.- Lymphogenesis induction.- (Pre)vascularisation.- Channels for vascularisation.- Additive manufacturing.- Mechanical molds.- Lost molds.- Decellularized vessel trees.- Microvascular approaches.- Cellular network formation.- Dual level approach.- Vascular grafts.

Wolfgang Holnthoner obtained both his M.Sc. in microbiology and genetics and his Ph.D. in molecular biology from the University of Vienna, Austria. For more than 20 years he has been working on endothelial cells, both from blood and lymphatic vessel origin. After his postdoctoral training with Kari Alitalo at the University of Helsinki, Finland, where he has been exploring signal transduction in lymphatic endothelial cells, he started at the Ludwig-Boltzmann-Institute for Experimental and Clinical Traumatology to work on strategies for pre-vascularization of tissue-engineered constructs. He is interested in the basic functions of endothelial cells in vasculogenesis, angiogenesis, and lymphangiogenesis. His group’s primary focus is the regeneration/engineering of microvascular structures. To this aim, he employs co-culturing primary endothelial cells with supporting cell types to achieve functional oxygen and nutrient support of tissues. Dr. Holnthoner uses the physiological and biocompatible scaffold fibrin to provide cells the necessary 3D environment for microvascularization. In addition, his research involves the integration of lymphatic vessels, since they are the ones that transport the interstitial fluid in tissues back to the blood circulation, and without them, human life would be inconceivable. Moreover, he strives to explore the emerging role of extracellular vesicles (EV) in intercellular communication. These efforts contribute to the development of therapies aimed for regeneration of diseased tissues.

Andrea Banfi directs the Cell and Gene Therapy research group at the University Hospital of Basel, Switzerland. He previously worked in Genova (Italy) and Stanford (CA, USA). His research focuses on: 1) understanding the basic principles governing the growth of blood vessels, particularly the molecular crosstalk between endothelium, mural cells and inflammatory monocytes, in

Discusses both fundamental and cutting-edge research

Includes contributions from the TERMIS community

Written by international experts in the field

Date de parution :

Ouvrage de 565 p.

15.5x23.5 cm

Disponible chez l'éditeur (délai d'approvisionnement : 15 jours).

474,74 €

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