Vascular Ion Channels in Physiology and Disease, 1st ed. 2016

Ion channels are the major class of membrane proteins responsible for rapid and regulated transport of ions across biological membranes and for the generation and propagation of electrical signals in the brain, heart, and skeletal and vascular tissues. Ion channels are also known to play critical roles in regulation of cell proliferation, insulin secretion and intracellular signaling in a variety of cell types. This book focuses on the roles of ion channels in vascular tissues under normal and pathological conditions.  Vascular abnormalities are known to underlie a plethora of severe pathological conditions, such as atherosclerosis, systemic and pulmonary hypertension, coronary or cerebral vasospasm, and diabetes. In addition, misregulated angiogenesis is one of the major contributors to the development of tumors. Therefore, it is clearly imperative to obtain a better understanding of the molecular mechanisms that contribute to vascular disorders. This book will be the first comprehensive assembly of assays to present the studies that have been done during the last decade to elucidate the roles of ion channels in different vascular diseases.

William F. Jackson
I.2.3. Abnormalities of Vascular Ion Channels during Hypertension

I.2.4. Kv7 Potassium Channels as Therapeutic Targets in Cerebral Vasospasm

Bharath K. Mani, Lyubov I. Brueggemann, Sarkis Morales-Vidal, Christopher M. Loftus, and Kenneth L. Byron

I.2.5. Lysosomal Transient Receptor Potential Mucolipin (TRPML) Channels in Vascular Regulation and Diseases 

Fan Zhang, Pin-Lan Li

II. Ion channels in the regulation of cell proliferation, remodeling, hypertrophy and angiogenesis

II.1. Calcium Mobilization via Intracellular Ion Channels, Store Organization and Mitochondria in Smooth Muscle

John G. McCarron, Susan Chalmers, Calum Wilson & Mairi E. Sandison

II.2. Role of mechanosensitive TRP channels in Abnormal Vasculature of Tumors 

Holly C. Cappelli, Roslin J. Thoppil, Ravi K. Adapala, J. Gary Meszaros, Sailaja Paruchuri, and Charles K. Thodeti

II.3. TRPC and Orai channels in store-operated calcium entry and vascular remodeling

David J Beech, Jing Li, Lynn McKeown, and Hollie L Appleby

II.4. Smooth muscle cell ion channels in pulmonary arterial hypertension: pathogenic role in pulmonary vasoconstriction and vascular remodeling

Ramon J. Ayon, Haiyang Tang, Ruby A. Fernandez, Ayako Makino, and Jason X.-J. Yuan

III. Ion channel regulation by lipids and channel modifications in metabolic disease

III.1. Physiological roles and cholesterol sensitivity of endothelial inwardly-rectifying K+ channels: specific cholesterol-protein interactions through non annular binding sites 

Irena Levitan, Sang Joon Ahn, Ibra Fancher, Avia Rosenhouse-Dantsker

III.2. Membrane lipids and modulation of vascular smooth muscle ion channels

Alex M. Dopico, Anna N. Bukiya and Guruprasad Kuntamallappanavar

III.3. Transient receptor potential channels in metabolic syndrome-induced coronary artery disease

Stacey L. Dineen, Zachary P. Neeb, Alexander G. Obukhov, and Michael Sturek

III.4. Mitochondrial ion channels in metabolic disease

Aaron H Truong, Saravanakumar Murugesan, Katia D Youssef, and Ayako Makino

Index

Alex Dopico, PhD, MD, is Chair of Pharmacology and Distinguished Professor at the University of Tennessee Health Science Center, Memphis, Tennessee.  His research interest focuses on the molecular interactions between small amphiphilic ligands, such as alcohol, and oligomeric ion channel proteins in excitable tissues, with a particular focus on cerebral artery smooth muscle.  Emphasis is put on determining site(s) of action and ion channel gating mechanisms targeted by the amphiphiles, role of membrane lipid microenvironment in regulating ligand-ion channel interaction, and consequences of such interaction on tissue and organ function.  Dr. Dopico currently holds a Merit Award from NIAAA, and also served as editor of the book Methods in Membrane Lipids published by Humana in 2007.