Vaccines against Allergies, 2011 Current Topics in Microbiology and Immunology Series, Vol. 352

We are celebrating this year the hundred years? anniversary of allergen-specific immunotherapy. In 1911 Leonard Noon published his seminal work ?Prophylactic inoculation against hay fever? describing his attempts to achieve active immunity against ?grass pollen toxin? by administering increasing doses of grass pollen extract before the grass pollen season to allergic patients. Although it was unknown at that time that allergy represents an immunological hypersensitivity disease, the treatment was effective and many observations made by Noon remained valid until today. Today allergen-specific immunotherapy is well established as the only allergen-specific and disease-modifying treatment for IgE-mediated allergies and has long-lasting effects. In fact, more than 25% of the population suffer from IgE-mediated allergies which therefore represent a major health burden of our society, particularly because untreated allergy often progresses to severe disabling forms of disease, such as asthma and sometimes kills sensitized people through anaphylaxis.

Preface.- Immunological approaches for tolerance induction in allergy.- Clinical experience with recombinant molecules for allergy vaccination.- Allergen-specific immunotherapy with recombinant allergens.- Vaccine approaches for food allergy.- Intralymphatic immunotherapy: From the rationale to human applications.- Induction of allergen-specific tolerance via mucosal routes.- T cell epitope-based allergy vaccines.- Allergen-specific immunotherapy: Towards combination vaccines for allergic and infectious diseases.- Cell-based therapy in allergy.- Subject index.