Tumor Microenvironment, 1st ed. 2021 Signaling Pathways – Part B Advances in Experimental Medicine and Biology Series, Vol. 1270

Alexander Birbrair received his Bachelor’s Biomedical degree from Santa Cruz State University in Brazil. He moved to North Carolina, where he finished his PhD in Neuroscience under the mentorship of Osvaldo Delbono. Then, he joined as a posdoc in Stem Cell Biology at Paul Frenette’s laboratory at Albert Einstein School of Medicine. In 2016, he was appointed faculty at Federal University of Minas Gerais in Brazil, where he started his own lab. His laboratory is interested in understanding how the cellular components of different tissues function and control disease progression. His group explores the roles of specific cell populations in the tissue microenvironment by using state-of-the-art techniques. His research is funded by the Serrapilheira Institute, CNPq, CAPES, and FAPEMIG. In 2018, Alexander was elected affiliate member of the Brazilian Academy of Sciences (ABC), and, in 2019, he was elected member of the Global Young Academy (GYA). He is the Editor-in-Chief of Current Tissue Microenvironment Reports, and associate editor of Molecular Biotechnology. Alexander also serves in the editorial board of several other international journals: Stem Cell Reviews and Reports, Stem Cell Research, Stem Cells and Development, and Histology and Histopathology.

Provides a comprehensive overview of the state-of-the-art research on how the tumor microenvironment exploits signaling pathways to fuel cancer progression Describes several different signaling pathways in the tumor microenvironment, including Src, Neuregulin, Adenosine, TGFß, Androgen, Wnt signaling, and more Illustrates in copious detail how cells in the tumor microenvironment co-opt signaling pathways to regulate cancer cells proliferation, survival, and invasion of other tissues