Treatment Resistance in Psychiatry, 1st ed. 2019 Risk Factors, Biology, and Management

This book reviews all the important aspects of treatment-resistant psychiatric disorders, covering issues such as definitions, clinical aspects, neurobiological correlates, treatment options, and predictors of treatment response. The book is divided into three sections, the first of which examines the most recent thinking on treatment resistance in psychiatry, including definition and epidemiology, paradigm shift in the study of the subjects, individual susceptibility and resilience, abnormal structural or functional connectivity, and insights from animal models. The second section then discusses treatment resistance in each of the major psychiatric disorders, with particular focus on the responsible clinical and biological factors and the available management strategies. Finally, more detailed information is presented on diverse pharmacological and non-pharmacological therapeutic interventions. The book, written by leading experts from across the world, will be of value to all who seek a better understanding of the clinical-neurobiological underpinnings and the development of management for treatment resistance in psychiatric disorders.

Part I. Rethinking the treatment resistance in psychiatry

 

Chapter 1. Definition and epidemiology of treatment resistance in psychiatry

Sanne Smith-Apeldoorn, Jolien Veraart, Robert Schoevers

Department of Psychiatry, University Medical Center Groningen, University of Groningen, the Netherlands

 

Chapter 2. Paradigm shift in study of treatment resistant psychiatric disorder

Sang-Won Jeon ¹ Meysam Amidfar,² Yong-Ku Kim³

¹ Department of Psychiatry, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea

² Department of Neuroscience, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran

³ Department of Psychiatry, College of Medicine, Korea University, Seoul, Republic of Korea

 

Chapter 3. Genetic factors underlying treatment resistance in psychiatry

Eduard Maron, Chenchia Lan, David Nutt

Faculty of Medicine, Department of Medicine, Centre for Neuropsychopharmacology, Division of Brain Sciences, Imperial College London, London, UK

 

Chapter 4. Using neuroimaging and electroencephalography for

prediction of treatment resistance in psychiatric disorders

 

Je_Yeon Yun, ¹Seung-Hwan Lee²

¹Seoul National University Hospital, Seoul, Republic of Korea

² Department of Psychiatry, Ilsan Paik Hospital, Inje University College of Medicine,

Republic of Korea.

 

Chapter 5. Developing therapies for treatment-resistant depressive disorders in animal models

Michel Bourin
Neurobiology of anxiety and mood disorders, University of Nantes, France

 

Chapter 6. Integrated approaches to treatment-resistant psychiatric disorders

Seon-Cheol Park,¹ Yong-Ku Kim²

¹ Department of Psychiatry, Inje University College of Medicine and Haeundae Paik Hospital, Busan, Republic of Korea

² Department of Psychiatry, College of Medicine, Korea University, Seoul, Korea

 

 

Part II. Treatment resistance in specific disorders

 

Chapter 7. Treatment resistant depression: understandings on the neurobiological etiology that lead to novel pharmacological treatment options

Eunsoo Won, Byoung-Joo Ham, Yong-Ku Kim,

Department of Psychiatry, College of Medicine, Korea University, Seoul, Korea

 

Chapter 8. Treatment Resistant Schizophrenia: assessment and management

Sandeep Grover, Harsh Garekar, Anisha Agarwal
Department of Psychiatry, Postgraduate Institute of Medical Education and Research, Chandigarh, India

 

Chapter 9. Treatment resistance in bipolar disorders

Marsal Sanches, Joao Quevedo, Jair C, Soares

Center of Excellence on Mood Disorders, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA.

 

Chapter 10. Treatment resistance in post-traumatic stress disorder

Alexander Cowell McFarlane,

The Centre for Traumatic Stress Studies, The University of Adelaide, Adelaide, Australia

Chapter 11. Treatment resistance in obsessive compulsive disorder

Rachel Middleton, Michael G. Wheaton, Reilly Kayser, H. Blair Simpson

New York State Psychiatric Institute/Columbia Psychiatry, Columbia University Medical Center, New York, USA

 

Chapter 12. Treatment of opioid dependence

Michael Soyka,

Psychiatric Hospital, University of Munich, Munich, Germany

 

Chapter 13. Treatment-resistant panic disorder

Mu-Hong Chen, Shih-Jen Tsai,

Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan

 

Chapter 14. Treatment resistance in anxiety disorder: generalized anxiety disorder, social anxiety disorder

Kang Soo Lee, Sang Huk Lee

Department of Psychiatry, School of Medicine, CHA University, CHA Bundang Medical Center, Seongnam, Korea

 

Chapter 15. Treatment resistance in Attention-Deficit Hyperactivity Disorder

Amber D. Hunt, David W. Dunn, Hillary S. Blake, Jen Downs

Department of Psychiatry and Neurology, Riley Hospital Child and Adolescent Psychiatry Clinics, Indiana University School of Medicine, Indianapolis, USA.

 

Chapter 16. Treatment resistance in Tourette syndrome

Renata Rizzo,¹ Mariangela Gulisano^2
1Child and Adolescent Neurology and Psychiatry, School of Medicine, University of Catania, Catania, Italy

² Child and Adolescent Neurology and Psychiatry Clinics, Policlinico, Catania, Italy

 

Chapter 17. Treatment-Resistance Eating Disorders

Youl-Ri Kim,, Jione Kim

Department of Psychiatry, Seoul Paik Hospital, Institute of Eating Disorders and Mental Health, Inje University, Seoul Paik Hospital, Inje University, Republic of Korea

 

Chapter 18. Comorbid sleep and wake problems in treatment-resistant psychiatric conditions

 

Seung Gul Kang,¹ Heon-Jeong Lee,² Yong-Ku Kim,² Leen Kim²  

¹Department of Psychiatry, Gil Medical Center, Gachon University, College of Medicine, Incheon, Republic of Korea

²Department of Psychiatry, Korea University College of Medicine, Seoul, Republic of Korea

 

Part III. Therapeutic intervention for treatment resistance

 

Chapter 19. Creative, person-centered psychopharmacology for treatment resistance in psychiatry

Miro Jakovljevic

University Hospital Centre Zagreb, Department of Psychiatry, Zagreb, Croatia

 

Chapter 20. A psychodynamic approach to treatment resistance

Elizabeth Weinberg, Erin Seery, Eric M. Plakun,

The Austen Rigges Center, Stockbridge, MA, USA

 

Chapter 21. Cognitive behavioral therapy and behavioral activation therapy for treatment resistant depression: traditional and digital therapy perspectives

Jennifer A. Apolinário-Hagen, Lara Fritsche, Liesemarie Albers, Christel Salewski

Department of Health Psychology, University of Hagen, Hagen, Germany.

 

Chapter 22. Novel neurostimulation therapeutic approaches for treatment resistant psychiatric disorders

Ralph J. Koek, Janine Roach, Nicholas Athanasiou, Arkady Korotinsky

Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at the UCLA, Los Angeles, USA

 

Chapter 23. When clozapine fails: augmentation strategies in the management of clozapine-resistant schizophrenia

 

Domenico De Berardis,¹ Michele Fornaro, Annalisa Anastasia, Federica Vellante , Alessandro Valchera, Marilde Cavuto, Giampaolo Perna, Marco Di Nicola, Gianluca Serafini, Alessandro Carano, Maurizio Pompili, Laura Orsolini, Carmine Tomasetti, Gabriella Di Emidio, Giovanni Martinotti, Massimo Di Giannantonio

¹NHS, Department of Mental Health, Psychiatric Service of Diagnosis and Treatment, Hospital “G. Mazzini”, ASL 4 Teramo, Italy

 

Chapter 24. Fecal microbiota transplantation in the treatment resistant psychiatric disorders

Alper Evrensel, Mehmet Emin Ceylan

Department of Psychiatry, Uskudar University, Istanbul, Turkey

 

Chapter 25. Neurosurgical intervention for treatment-resistant psychiatric disorders

Daniel E. Nijensohn,¹ Teodoro Forcht Dagi ²

¹Honorary Professor, Department of Neurosurgery, Yale University School of Medicine, New Haven, CT, USA

² Distinguished Scholar and Professor at the School of Medicine, Dentistry and Biomedical Sciences, Queen’s University, Belfast, Northern Ireland