Therapeutic potential of Cell Cycle Kinases in Breast Cancer, 2023

This book highlights the interrelation between cell cycle regulators and breast cancer phenotypes. It reviews the roles of Cyclin-Dependent Kinases (CDK) in driving cell cycle progression, cell cycle checkpoints and dysregulation in breast cancer. It also examines the prognostic significance of CDKs in breast cancer. and CDK inhibitors for the treatment of metastatic breast cancer. Further, the book discusses the role of different G1 cyclins in differentiation, chromosome stability, and transcriptional regulation in breast cancer. Additionally, it examines the role of immunogenic effects of CDK inhibitors, the mechanism of resistance and the current clinical trials in breast cancer treatment. Towards the end, the book explores cell cycle regulation as an attractive target for targeted drug therapy in breast cancer. This book is a comprehensive yet concise resource for oncologists and researchers interested in exploring the therapeutic potential of Cyclin-Dependent Kinases in breast cancer.

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Dr. Manzoor Ahmad Mir is Coordinator and the Head of Department of Bioresources, School of Biological Sciences at University of Kashmir, India. He has served as Nodal officer of Kupwara Campus of Kashmir University and Nodal officer of Internal quality assurance at the University.  He has served as referee/reviewer for a number of International journals and has more than 15 years of teaching experience in Cancer Biology, Immunology, Molecular Biology, Animal Biotechnology, Cell culture and Tissue Technology. Dr. Manzoor Ahmad Mir holds Master’s Degree in Zoology from HNBG Central University and after qualifying prestigious National level CSIR-JRF-NET examination; he worked jointly for his Ph. D at Jawaharlal Nehru University New Delhi and CSIR-Institute of Microbial Technology Chandigarh in the field of Immunopathology. His basic research interests include, molecular immunology and Immunobiology of microbes (MTB). His Ph D research title was “Role of co-stimulation in the survival of intracellular pathogens”.

He has also published more than 40 research articles in the peer-reviewed international journal and authored 15 Books with international Publishers. Dr Manzoor was awarded Teachers Associate Research Excellence Fellowship (TARE) by DST Govt of India Summer Research Fellowship Programme (SRFP-2019) by Indian Academy of Sciences and National Science Academy. He was awarded a research project on combination therapy in breast cancer by Jammu Kashmir Science Technology and Innovation council, Govt of J&K. Dr Manzoor has developed Massive Open Online Course (MOOCs) in Immunology course and Endocrinology course for UG students sanctioned by UGC-Consortium for Educational Communication (CEC) SWAYAM Ministry of HRD Govt of India. He currently teaches Cancer Biology, and Immunology at the Department of Bioresources, School of Biological Sciences, University of Kashmir.

Discusses role of Cyclin-Dependent Kinases (CDK) in breast cancer progression and treatment Reviews CDKs as promising target for cancer therapy Examines clinical role of CDK 4/6 inhibitors in metastatic breast cancer