The Kidney and Hypertension in Diabetes Mellitus (4^th Ed., 4th ed. 1998. Softcover reprint of the original 4th ed. 1998)

We have witnessed a rapid development within the field of the kidney and hypertension in diabetes mellitus. A significant amount of work within the traditional areas has been published, and several new dimensions are now being developed, mostly in the experimental setting. These dimensions are discussed in several chapters of this new edition, The Kidney and Hypertension in Diabetes Mellitus, FourthEdition.
This volume endeavors to cover all aspects of renal involvement in diabetes. It is written by colleagues who are themselves active in the many fields of medical research covered in this volume: epidemiology, physiology and pathophysiology, laboratory methodology and renal pathology.

1. Historical aspects of diabetes and diabetic renal disease.- 2. The nature of the diabetic glomerulus: pressure-induced and metabolic aberrations.- 3. Definition of diabetic renal disease in insulin-dependent diabetes mellitus based on renal function tests.- 4. Retinopathy in relation to albuminuria and blood pressure in IDDM.- 5. Microalbuminuria and cardiovascular disease.- 6. The heart in diabetes: result s of trials.- 7. Albuminuria in non-insulin-dependent diabetes — renal or extra renal disease ?.- 8. The clinical course of renal disease in Caucasian NIDDM-patients.- 9. Use of albumin/creatinine ratio in patient care and clinical studies.- 10. Serum creatinine and other measures of GFR in diabetes.- 11. Familial factors in diabetic nephropathy.- 12. Genetics and diabetic nephropathy.- 13. The concept of low birth weight and renal disease.- 14. Effect of insulin on the kidney and the cardiovascular system.- 15. Diabetes, hypertension, and kidney disease in the PIMA Indians.- 16. Value of screening for microalbuminuria in people with diabetes as well as in the general population.- 17. Incidence of nephropathy in IDDM as related to mortality. Cost and benefits of early intervention.- 18. Measurement of albumin and other urinary proteins in low concentration in diabetes mellitus: techniques and clinical significance.- 19. Office tests for microalbuminuria.- 20. Exercise and the kidney in diabetes.- 21. Von Willebrand factor, dysfunction of the vascular endothelium, and the development of renal and vascular complications in diabetes.- 22. Smoking and diabetic nephropathy.- 23. Light microscopy of diabetic glomerulopathy: the classic lesion.- 24. Renal ultrastructural changes in microalbuminuric IDDM-patients.- 25. Renal structure in non insulin-dependent diabeticpatients with microalbuminuria.- 26. Sodium-hydrogen antiport, cell function and susceptibility to diabetic nephropathy.- 27. Advanced glycation end-products and diabetic renal disease.- 28. Protein kinase C in diabetic renal involvement, the perspective of inhibition.- 29. Biochemical aspects of diabetic nephropathy.- 30. The Steno hypothesis and glomerular basement membrane biochemistry in diabetic nephropathy.- 31. Volume homeostasis and blood pressure in diabetic states.- 32. Pathogenesis of diabetic glomerulopathy: the role of glomerular hemodynamic factors.- 33. The role of growth hormone, insulin-like growth factors, epidermal growth factor and transforming growth factor-? in diabetic kidney disease: An update.- 34. Transforming growth factor beta and other cytokines in experimental and human diabetic nephropathy.- 35. Blood pressure elevation in diabetes: the results from 24-h ambulatory blood pressure recordings.- 36. Lipidaemia and diabetic renal disease.- 37. Microalbuminuria in young patients with type 1 diabetes.- 38. Early renal hyperfunction and hypertrophy in IDDM patients including comments on early intervention.- 39. ACE-inhibition and angiotensin II receptor blockade, and diabetic nephropathy.- 40. The concept of incipient diabetic nephropathy and effect of early antihypertensive intervention.- 41. Clinical trials in overt diabetic nephropathy.- 42. Antihypertensive treatment in NIDDM, with special reference to abnormal albuminuria.- 43. The course of incipient and overt diabetic nephropathy: the perspective of more optimal insulin treatment.- 44. Non-glycaemic intervention in diabetic nephropathy: the role of dietary protein intake.- 45. Microalbuminuria and diabetic pregnancy.- 46. Diabetic nephropathy and pregnancy.- 47. Evolution worldwide ofrenal replacement therapy in diabetes.- 48. Hemodialysis in type 1 and type 2 diabetic patients with endstage renal failure.- 49. Continuous ambulatory peritoneal dialysis in uremic diabetics.- 50. Renal transplantation for diabetic nephropathy.- 51. Prevention of diabetic renal disease with special reference to microalbuminuria.- 52. Combination therapy for hypertension and renal disease in diabetes.- 53. Microalbuminuria in patients with essential hypertension. Cardiovascular and renal implications.- 54. A comparison of progression in diabetic and non-diabetic renal disease: similarity of progression promoters.