The Ischemic Heart, 1998 Progress in Experimental Cardiology Series, Vol. 1

Over the past three decades, impressive progress in the field of pathogenesis, prevention and therapy of ischemic heart disease has resulted in a marked decline in mortality in the Western World. However, the incidence of this devastating disease is on the rise in developing countries.
The Ischemic Heart is based upon a recent symposium in Tokyo on the subject. This volume is organized into two sections: (i) Pathophysiologic Mechanisms of Ischemia-Reperfusion Injury and (ii) Preconditioning and Protection of Ischemia-Reperfusion Injury, and contains up-to-date information concerning the current concepts of ischemia-reperfusion injury, the sequence of events resulting in the loss of contractile dysfunction, and mechanisms of cardioprotection by several drugs as well as the role of ischemic preconditioning in attenuating problems associated with ischemia-reperfusion injury.

Preface. A: Pathophysiologic Mechanisms of Ischemia-Reperfusion Injury. 1. Function of Cardiac Myocytes in Ischemic Heart Disease: Comparative Changes in Right and Left Ventricular Cells; S.E. Harding, et al. 2. Remodeling of Cardiac Myocytes in Chronic Heart Disease; A.M. Gerdes. 3. Hibernating Myocardium; R. Ferrari. 4. Length-Dependent Modulation of Cardiac Muscle Contractility in Normoxia, Hypoxia and Acidosis; K. Hongo, et al. 5. Roles of Superoxide, Nitric Oxide and Peroxynitrite in Various Pathological Conditions; H. Ishida, et al. 6. Real-Time Measurement of Nitric Oxide in Coronary Outflow During Transient Myocardial Ischemia and Reperfusion; Y. Fukuhiro, et al. 7. Production of Hydrogen Peroxide During Hypoxia-Reoxygenated in Isolated Myocytes; R. Ueda, et al. 8. Oxygen Free Radicals Enhance Ergonovine-Induced Canine Coronary Vasoconstriction; T. Konno, et al. 9. Structure and Expression of Calponin in Arterial Smooth Muscle Cells; H. Yamamura, et al. 10. Status of beta-Adrenoceptors, G-Proteins and Adenylyl Cyclase in Ischemic Heart Disease; N.S. Dhalla, et al. 11. Oxygen Consumption and Mitochondrial Membrane Potential in Post-Ischemic Myocardium; K. Nishio, et al. 12. Pathophysiological Behavior of the Myocardium in Acute Ischemia and Reperfusion - With Special Emphasis on the Sarcoplasmic Reticulum; T. Katagiri, et al. 13. Ca2+ Ion Shifts in Vivo in Reversible and Irreversible Ischemic Injury; R.B. Jennings, C. Steenbergen. 14. Ionic Mechanisms of Reperfusion Injury; M.J. Shattock. 15. Mechanism of Inhibition of Na+/H+ Exchanger (NHE1) by ATP Depletion: Implication to Myocardial Ischemia; T. Ikeda, et al. 16. The Source and Fate of Protons in the Reperfused Ischemic Heart; G.D. Lopaschuk, A.S. Clanachan. 17. Intracellular Calcium Regulation in Cardiac Cells During Acidosis; C.M.N. Terracciano, K.T. MacLeod. 18. Intracellular pH Regulation and Myocardial Ischemia/Reperfusion Injury; D. Feuvray. 19. Regulation of [Na+]i and [Ca2+]i During Myocardial Ischemia and Reperfusion in a Single Cell Model; H. Hayashi, et al. 20. ATP-Sensitive Potassium Channels and Myocardial Ischemia; C. Jiang, et al. B: Preconditioning and Protection of Ischemia-Reperfusion Injury. 21. Early and Delayed Protection Against Ventricular Arrhythmias Induced by Preconditioning; A. Vegh, et al. 22. Effects of Ischemic Preconditioning on Na+Ca2+ Exchanger Activity and Ion Regulation in Isolated Perfused Rat Hearts; S. Seki, et al. 23. Long-Term But Not Short-Term Cardio-Protection Can Be Induced by `Preconditioning' in Hypercholesterolemia; L. Szekeres, et al. 24. Contribution of Endogenous Catecholamines to Preconditioning: Is it Through Facilitation of Adenosine Production? K. Suzuki, et al. 25. Hypoxic Preconditioning of Isolated Cardiomyocytes of Adult Rat; M. Nojiri, et al. 26. Pharmacological Modification of Ischemic Preconditioning During Percutaneous Transluminal Coronary Angioplasty; T. Ueda, et al. 27. Protection Against Injury During Myocardial Ischemia and Reperfusion: Concepts and Strategies; D.J. Hearse.