The Endometrial Factor A Reproductive Precision Medicine Approach

At the dawn of precision medicine, there is a new opportunity for novel approaches to understand, diagnose and treat endometrial disorders that affect fertility, reproductive outcomes, and women?s health more broadly. Herein, the editors have assembled critically evaluated state-of-the-art chapters presenting basic and clinical knowledge about the human endometrium that impacts or will impact clinical practice. All clinicians and researchers in Reproductive Medicine will find this book useful as a reference and a valuable tool for continued advancement in the understanding and management of the "endometrial factor".

Preface. Foreword: An eye to the future. Highlights on the dynamism and multifunctionality of human endometrium in the era of precision medicine. Diagnosis of the Endometrial Factor: New imaging diagnostics. Molecular diagnosis of endometrial receptivity. Molecular diagnosis of endometriosis. Microbiological diagnosis: The human endometrial microbiome-endometritis. Hysteroscopy: An invasive diagnosis. Personalization of the Endometrial Factor: The endometrium in Polycystic Ovary Syndrome. Obesity and the endometrium. Uterine fibroids and the endometrium. New knowledge about adenomyosis. Therapeutic Options of the Endometrial Factor: Hormonal regulation of the endometrium and the effects of hormonal therapies. Abnormal Uterine Bleeding (previously Dysfunctional Uterine Bleeding): How to manage. Inflammation of the endometrium in reproduction. Empirical treatments to improve receptivity: Why not?. Endometrial scratching. Stem Cell Therapies for Atrophic Endometrium and Asherman´s Syndrome. Gestational surrogacy. Uterine transplantation. The Ultimate Goal: Embryo/fetal-maternal cross-talk. Embryo transfer: Fresh, deferred, personalized? Reproductive and obstetrical outcomes.

Carlos Simón M.D., PhD is Professor of Obstetrics and Gynecology at the University of Valencia, Spain; Adjunct Clinical Professor, Department of Ob/Gyn, Stanford University School of Medicine, CA, USA; Scientific Director of Instituto Valenciano de Infertilidad (IVI) and IGENOMIX. Linda C Giudice MD, PhD, MSc is Distinguished Professor and Chair, The Robert B. Jaffe, MD Endowed Professor in the Reproductive Sciences, University of California at San Francisco, CA, USA.