The Cerebral Cortex in Neurodegenerative and Neuropsychiatric Disorders Experimental Approaches to Clinical Issues
Coordonnateurs : Cechetto David F., Weishaupt Nina
The Cerebral Cortex in Neurodegenerative and Neuropsychiatric Disorders: Experimental Approaches to Clinical Issues focuses on how pre-clinical investigations are addressing the clinical issues surrounding the involvement of the cerebral cortex in selected conditions of the nervous system, including Alzheimer?s Disease, Parkinson?s, addiction, and cardiovascular dysregulation.
Each chapter is written by an expert in his/her field who provides a comprehensive review of the clinical manifestations of cortical involvement and experimental techniques currently available to tackle cortical issues in disease. Thus, this present title provides a link between cortical clinical problems and investigational approaches to help foster future research with high translational value.
Part I. Introductory Chapters
Chapter 1. Anatomy of the Cerebral Cortex
Chapter 2. Cortical Plasticity in Response to Injury and Disease
Chapter 3. Imaging Approaches to Cerebral Cortex Pathology
Part II. The Cerebral Cortex in Neurodegenerative Disorders
Chapter 4. Alzheimer’s Disease
Chapter 5. Vascular Dementia
Chapter 6. Frontotemporal Dementia
Chapter 7. Parkinson’s Disease and the Cerebral Cortex
Chapter 8. Huntington Disease
Chapter 9. Cortical Manifestations in Amyotrophic Lateral Sclerosis
Chapter 10. Cortical Involvement in Multiple Sclerosis
Part III. The Cerebral Cortex in Neuropsychiatric Disorders
Chapter 11. Prefrontal Cortical Abnormalities in Cognitive Deficits of Schizophrenia
Chapter 12. Role of the Prefrontal Cortex in Addictive Disorders
Dr. Nina Weishaupt trained as a veterinarian before committing her career entirely to research in the neurological sciences. Her PhD thesis work in the field of spinal cord injury at the University of Alberta earned her a Dissertation Fellowship and resulted in a number of published articles. Nina has extensive experience with animal models of neurological conditions, and is currently developing a novel rat model for studying early events in the development of Alzheimer’s Disease at the University of Western Ontario.
- Offers a comprehensive overview on the best available in vivo and in vitro models to study cortical involvement
- Presents models and specific techniques that help to guide investigators in their choices on how to address research questions experimentally
- Provides expert commentary and a perspective on future trends at the end of each chapter
- Addresses translational advances and promising therapeutic options
- Includes references to key articles for additional detailed study
Date de parution : 10-2016
Ouvrage de 340 p.
15x22.8 cm
Thèmes de The Cerebral Cortex in Neurodegenerative and... :
Mots-clés :
�-amyloid (A�)Neurofibrillary tangle (NFT)Oligomers; γ-Aminobutyric acid; (GABA)Glutamate; Activity-dependence; Addiction; Alzheimer's disease (AD)Amyloid plaques; Animal model; Animal models; Anterior cingulate cortex; Areas; Axonal sprouting; Bradykinesia; C9ORF72; CADASIL; Cerebral amyloid angiopathy; Cognitive impairment; Columns; Compensation; Connections; Cortical pathology; Dendritic spine; Dependence; Diabetes; Dopamine (DA)Glutamate (GLUT)Mesocorticolimbic; Dopamine; Executive dysfunction; Experimental autoimmune encephalomyelitis (EAE)Magnetic resonance imaging (MRI)Multiple sclerosis (MS)Frontoinsular cortex; Frontotemporal dementia (FTD)Neural networks; Frontotemporal dementia (FTD)Primary progressive aphasia (PPA)Progranulin; Glutamate; Growth factor; Growth inhibitor; Homologies; Huntingtin (HTT)Huntington disease (HD)Hypertension; Infarct; Interneurons; Layers; Leukoencephalopathy; Mesocorticolimbic; Minicolumns; Motor cortex; Neurochemistry; Neurotrophin; Prefrontal cortex (PFC)Schizophrenia; Prefrontal cortex (PRC)Reward; Prefrontal cortex; Proteinopathy; Pyramidal neurons; Reward; Salience network; Social cognition; Stroke; Synaptic strength; Tau; Tremor
