Systematic Approach to Evaluation of Mouse Mutations

Experts from The Jackson Laboratory and around the world provide practical advice on everything from how to establish a colony to where to go for specific mutations. The book includes information on medical photography, grafting procedures, and how to map the genes and evaluate the special biological characteristics of mice. It also discusses how to maintain a colony of mice that breed with difficulty, how to approach mapping spontaneous mutations, how to set up systems to evaluate a specific antibody, how to perform simple measurements that yield a large amount of information, and how to access mouse informatics on the Web.

Mouse Colony Establishment-Determining the Genetic Basis of a New Trait-Xavier Montagutelli Computerized Colony Record Keeping-Medical Record Keeping for Project Analysis-Necropsy Methods for Laboratory Mice. Biological Characterization of a New Mutation- Photography of Mutant Laboratory Mice-Comparative Pathology and Animal Model Development-Kinetics and Morphometrics-Ultrastructural Evaluation of Mouse Mutations-Immunohistochemical and Immunofluoresence Methods-Radiolabeled cRNA and In Situ Hybridization-In Situ Hybridization with Non-Radiolabeled Probes-Repositories of Mouse Mutations and Inbred, Congenic and Recombitant Inbred Strains

Professional Practice & Development and Professional Reference

John P. Sundberg, Dawnalyn Boggess