The Fundamentals of Stereoelectroencephalography

Gain confidence and expertise with stereoelectroencephalography (SEEG) as a presurgical method for epilepsy with this helpful resource. Edited and written by leading experts in the field, Stereoelectroencephalography teaches the scientific and medical bases of SEEG through its essential disciplines (anatomy, biophysics, electrophysiology, and cognitive and behavioral neuroscience) and their interrelations. It fully covers the basic and clinical aspects of the pharmaco-resistant epilepsies investigated with SEEG and their surgical indications.

• Describes the evolution in time of the presurgical methods leading to the current practice of SEEG.

• Explains how to determine the anatomical basis of electrode implantation, its referential system, and how it prepares rational planning to tailored resection or ablation.

• Examines the nature of the SEEG signal, how the depth electrodes capture it, and how the dynamics of multiple cortical sites recording can be understood.

• Contains chapters on key topics such as the optimal SEEG electrode, intracerebral electrodes implantation technique, seizure onset: interictal, preictal/ictal patterns and the epileptogenic zone, how to define the extent of the EZ by applying signal processing methods, the role of SEEG in exploring lesional epilepsy cases, and much more.

• Presents the logical chain linking SEEG to anatomically pre-planned surgery.

• Includes discussions of in-depth illustrative cases.

• An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.

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After becoming an INSERM (Paris) researcher, Pr. Chauvel began his work in experimental and later clinical research into the mechanisms of the epilepsies. Under the mentorship of Talairach and Bancaud at Hopital Sainte-Anne, Paris, he developed SEEG (StereoElectroEncephalography) as a presurgical method in epilepsy surgery. His research work has been devoted to the neurophysiology of the epileptogenic zone, emergence of seizure clinical semiology in relation to intracerebral recording, and cerebral cortex physiology. He has promoted the concept of epileptogenic network over the classical epileptic focus idea, and opened new vistas in markers of the epileptogenic zone and pathophysiology of frontal epilepsies. Pr. Chauvel served as the Director of the SEEG Unit in Hôpital Sainte-Anne in Paris (1986-1990), then Professor and Chairman of Neurology in Rennes (1990-1997) where he configured a new type of Epilepsy Unit including research, then Professor and Chairman of Clinical Neurophysiology and Director of the INSERM Institute of Systems Neuroscience in Marseille (1997-2014). In 2014, he relocated to the Epilepsy Center of the Cleveland Clinic, in order to promote the development of presurgical investigation using SEEG in North America. He is the author of 250 original articles in international journals and is a member of several Scientific and Medical Societies, both French and International. He has been elected as a Member of the Belgian Royal Academy of Medicine.
Jorge Gonzalez-Dominguez is Postdoctoral researcher at the Johannes Gutenberg University Mainz, Germany. He completed his PhD degree in the area of High Performance Computing at the University of A Coruña, Spain. He has wide experience developing parallel algorithms using different technologies such as Pthreads, OpenMP, MPI, UPC, UPC++ and CUDA. His work has been published in international journals (e.g. IEEE/ACM Transactions on Computational Biology and Bioinformatics, Concurrency and Computation: Prac