Sirtuin Biology in Medicine Targeting New Avenues of Care in Development, Aging, and Disease

Sirtuin Biology in Medicine: Targeting New Avenues of Care in Development, Aging, and Disease provides a fascinating and in-depth analysis of sirtuins in the body during normal physiology as well during disease highlighting the targeting of sirtuin-controlled pathways for the development of innovative, efficacious, and safe therapeutic strategies for multiple disorders in the body that ultimately can affect lifespan extension. Sirtuins are expressed throughout the body, have broad biological effects, and can significantly impact both cellular survival and longevity during acute and long-term illnesses. These histone deacetylases play an intricate role in the pathology, progression, and treatment of several disease entities ranging from neurodegenerative disorders, cardiovascular disease, immune system dysfunction, reproductive dysfunction, endocrine disorders, gastrointestinal disease, drug dependency, and aging-related disorders. Implementing a translational medicine format, this unique reference highlights novel signaling pathways for sirtuins that promote stem cell proliferation, enhance cellular protection, modulate pathways of apoptosis and autophagy, and extend life span. Each chapter is presented with insightful detail that will be of interest and a comprehensive resource to audiences that include scientists, physicians, pharmaceutical industry experts, nutritionists, and students.

Section I: Sirtuins, neurodegenerative disease, lifespan extension, and aging
1. Novel treatment strategies for neurodegenerative disease with sirtuins
Kenneth Maiese
2. NAD1: a crucial regulator of sirtuin activity in aging
Nady Braidy And Maria Villalva (D.)
3. Sirtuins and life span extension
Shin-Hae Lee and Kyung-Jin Min
4. Sirtuins and aging
Brian J. Morris
5. Sirtuins in the biology of aging
Mateusz Watroba And Dariusz Szukiewicz
6. Sirtuins as regulators and the regulated molecules of exosomes
Qing Han, Yirui Cheng, and Weiliang Xia
7. Sirtuins in aging, age-related pathologies and their association with circadian rhythm
Sankarathi Balaiya
8. Sirtuins, mitochondria, and the melatonergic pathway in Alzheimer’s disease
G. Anderson and M. Maes
9. Sirtuins, melatonin, and the relevancevof circadian oscillators
Rüdiger Hardeland
10. Epigenetic role of sirtuins in neurodegenerative brain disorders
Archita Khanna, Anamika, and Surendra Kumar Trigun
11. Sirtuins and stem cell maintenance, proliferation, and differentiation
Ryan A. Denu and Peiman Hematti
12. Sirtuins in mechanistic target of rapamycin complex 1 signaling
J. Burillo, P. Marqués, B. Jiménez, C. González-Blanco, M. Benito, and C. Guillén
13. Free-radical redox timer, sirtuins and aging: from chemistry of free radicals to systems theory of reliability
Vitaly K. Koltover and Tatjana A. Skipa
14. Sirtuins, mitochondria, and exercise in health and disease
Anibh M. Das and Partha Dabke

Section II: Sirtuins, cardiovascular disease and end-organ disease
15. Scope to develop sirtuins modulators as a therapy to attenuate cardiac complications
Bugga Paramesha and Sanjay K. Banerjee
16. Role of sirtuins in cardiovascular diseases
Venkatraman Ravi, Sneha Mishra, and Nagalingam Ravi Sundaresan
17. Targeting sirtuins to modulate energy metabolism in heart disease
Tsunehisa Yamamoto and Ken Shinmura
18. Sirtuin 1 mediates hepatoprotective effects of resveratrol-like compounds in experimental liver injury
Hassan Farghali, Mighty Kgalalelo Kemelo, and Nikolina Kutinová Canová
19. Sirtuins as key players in aging and kidney dysfunction
Luca Perico and Ariela Benigni
20. Role of sirtuins in liver diseases
D. Ezhilarasan and M. Najimi
22. Vitagenes in avian biology: protective functions of sirtuins
Peter F. Surai, Ivan I. Kochish, and Vladimir I. Fisinin
23. Sirtuins in hematopoiesis and blood malignancies
Berta N. Vazquez, Irene Fernández-Duran, and Alejandro Vaquero
Index

Kenneth Maiese, MD, is an internationally recognized physician-scientist whose investigations are designed to translate basic science into successful therapeutic treatments. He maintains therapeutic and scientific expertise in multiple medical disciplines and has been fortunate to receive recognition with outstanding teaching and investigator awards, election to America’s Top Physicians and The Best of U.S. Physicians, recipient of Albert Nelson Marquis Lifetime Achievement Award, and elected as an America’s Health Insurance Plans (AHIP) Executive Leadership Fellow. His work has received the distinction of “High Impact Research and Potential Public Health Benefit” by the National Institutes of Health. As an internationally recognized physician researcher and “C-suite” healthcare leader, he has extensive experience in academic medicine, healthcare delivery, business development, managed care, biotechnology, and drug development holding positions as member and advisor for the National Institutes of Health Biotechnology and Venture Capital Development, National Institutes of Health Innovation Network, Chief Medical Officer, tenured Professor and Chair and Chief of Service of the Department of Neurology and Neurosciences of Rutgers University, Global Head of Translational Medicine and External Innovation, Board Member of the Cancer Institute of New Jersey, Steering Committee Member for the Foundation for the National Institutes of Health, tenured Professor in Neurology, Anatomy & Cell Biology, Molecular Medicine, the Barbara Ann Karmanos Cancer Institute, and the National Institute of Health Center at Wayne State University, and Founding Editor and Editor-in-Chief of multiple highly successful international journals.