Sex and Gender Differences in Alzheimer's Disease The Women's Brain Project

Sex and Gender Differences in Alzheimer?s Disease: The Women?s Brain Project offers for the first time a critical overview of the evidence documenting sex and gender differences in Alzheimer?s disease neurobiology, biomarkers, clinical presentation, treatment, clinical trials and their outcomes, and socioeconomic impact on both patients and caregivers. This knowledge is crucial for clinical development, digital health solutions, as well as social and psychological support to Alzheimer?s disease families, in the frame of a precision medicine approach to Alzheimer?s disease. This book brings together up-to-date findings from a variety of experts, covering basic neuroscience, epidemiology, diagnosis, treatment, clinical trials development, socioeconomic factors, and psychosocial support. Alzheimer?s disease, the most common form of dementia, remains an unmet medical need for the planet. Wide interpersonal variability in disease onset, presentation, and biomarker profile make Alzheimer?s a clinical challenge to neuroscientists, clinicians, and drug developers alike, resulting in huge management costs for health systems and society. Not only do women represent the majority of Alzheimer?s disease patients, but they also represent two-thirds of caregivers. Understanding sex and gender differences in Alzheimer?s disease will lead to novel insights into disease mechanisms, and will be crucial for personalized disease management strategies and solutions, involving both the patient and their family.

Endorsements/Reviews:

"There is a clear sex and gender gap in outcomes for brain health disorders like Alzheimer?s disease, with strikingly negative outcomes for women. This understanding calls for a more systematic way of approaching this issue of inequality. This book effectively highlights and frames inequalities in all areas across the translational spectrum from bench-to-bedside and from boardroom-to-policy and economics. Closing the Brain Health Gap will help economies create recovery and prepare our systems for future global shocks." Harris A. Eyre MBBS, PhD, co-lead, Neuroscience-inspired Policy Initiative, OECD and PRODEO Institute. Instructor in Brain Health Diplomacy, Global Brain Health Institute, UCSF and TCD.

"Sex and Gender Differences in Alzheimer's disease is the most important title to emerge on Alzheimer's disease in recent years.This comprehensive, multidisciplinary book is a must read for anyone with a serious interest in dementia prevention, diagnosis, treatment, care, cure and research. Precision medicine is the future of healthcare and this book represents an incredible and necessary resource to guide practice, policy and research in light of the fact that Alzheimer's disease disproportionately affects women. The combination of contributions from the most eminent experts and the most up-to-date research makes this an invaluable resource for clinicians, care providers, academics, researchers and policy makers. Given the complex nature of dementia and the multiple factors that influence risk and disease trajectory the scope of the book is both impressive and important covering sex differences in neurobiological processes, sex and gender differences in clinical aspects and gender differences linked to socioeconomic factors relevant to Alzheimer's disease. If you work in Alzheimer's disease, or indeed other dementias, then Sex and Gender Differences in Alzheimer's disease is a must have for your bookshelf." -- Sabina Brennan, PhD., C.Psychol.,PsSI., National representative for Ireland on Alzheimer Disease International's Medical and Scientific Advisory Panel

Introduction Part 1 Sex differences in fundamental neurobiological processes that are relevant to Alzheimer’s disease 1. Sex differences in Alzheimer’s disease animal model 2. Sex and sex hormone differences in hippocampal neurogenesis and their relevance to Alzheimer’s disease 3. Sex differences in microglia as a risk factor for Alzheimer’s disease

Introduction Part 2 Sex and gender differences in clinical aspects of Alzheimer’s disease 4. Sex differences in CSF biomarkers of Alzheimer’s disease 5. Sex differences in neuroimaging biomarkers in healthy subjects and dementia 6. Sex differences in neuropsychological symptoms for clinical diagnosis of Alzheimer’s disease 7. Sex differences in psychiatric disorders and their implication for dementia 8. Sleep disorders and dementia 9. Hormones and dementia 10. Sex and gender differences in genetic and lifestyle risk and protective factors for dementia 11. Sex and gender considerations in clinical trials for Alzheimer’s disease: Current state and recommendations

Introduction Part 3 Gender differences in the socio-economic factors linked to Alzheimer’s disease 12. Gender and socioeconomic differences in modifiable risk factors for Alzheimer’s disease and other types of dementia throughout the life course 13. Living with dementia and caregiving: Psychosocial considerations through the gender lens 14. Sex and gender differences in caregiving patterns and caregivers’ needs 15. Gender barriers to communication in Alzheimer’s disease 16. Women and dementia policy: Redressing imbalance through gender transformative policies

Based on your assessment of the proposal, in your view who is the audience for the project? Neurologists, neuroscientists, psychiatrists, psychologists, nurses, advanced practice practitioners and medical ethicists.

• Provides a comprehensive and critical review of sex differences in Alzheimer’s disease
• Features discussion of sex and gender differences in disease biology, treatment, and socioeconomic factors, including impact on caregivers
• Combines the knowledge and points-of-view of neuroscientists, medical doctors, psychologists, policymakers, health scientists, and clinical trial experts, for a 360-degree view on the topic and its possible implications
• Edited by the Women’s Brain Project, the leading NGO in the field of sex and gender differences in brain and mental health as the gateway to precision medicine