RNA Interference and Cancer Therapy, 1st ed. 2019 Methods and Protocols Methods in Molecular Biology Series, Vol. 1974
Coordonnateur : Dinesh Kumar Lekha
1. siRNA Library Screening to Identify Complementary Therapeutic Pairs in Triple Negative Breast Cancer Cells
Bindu Thapa, Remant Bahadur KC, and Hasan Uludağ
2. In Vitro Evaluation of Candidate Gene Targets for Cancer Therapy
Xing Fei Tan, Wei Xuan Teo, and George W. Yip
3. siRNA-Based Drug Targeting Human Bcl-xL against Cancers
Yoshifumi Takei
4. Relative Quantification of siRNA Strand Loading into Ago2 for Design of Highly-Active siRNAs
Phillip A. Angart, Kwasi Adu-Berchie, Rebecca J. Carlson, Daniel B. Vocelle, Christina Chan, and S. Patrick Walton
5. VEGFA Gene Silencing in CXCR4-Expressing Cells via siRNA Delivery by Means of Targeted Peptide Carrier
Anna A. Egorova, Marianna A. Maretina, and Anton V. Kiselev
6. Design Strategy to Access siRNA-Encapsulating DNA “Nanosuitcases” that Can Conditionally Release their Cargo
Katherine E. Bujold, Hassan H. Fakih, and Hanadi F. Sleiman
7. Combinatorial siRNA Polyplexes for Receptor Targeting
Dian-Jang Lee and Ernst Wagner
8. Synthesis of Doxorubicin and miRNA Stimuli-Sensitive Conjugates for Combination Therapy
Daniel F. Costa, Can Sarisozen, and Vladimir P. Torchilin
9. Minicell-Based Targeted Delivery of shRNA to Cancer Cells: An Experimental Protocol
Mehul Jivrajani and Manish Nivsarkar
10. Targeted Delivery of miRNA Antagonists to Myeloid Cells In VitroandIn Vivo
Yu-Lin Su, Piotr Swiderski, Guido Marcucci, and Marcin Kortylewski
11. Systemic Modulation of Lymphocyte Subsets Using siRNAs Delivered via Targeted Lipid Nanoparticles
Inbal Hazan-Halevy, Daniel Rosenblum, Srinivas Ramishetti, and Dan Peer
12. Targeting Cancer with Peptide RNAi Nanoplexes
A. James Mixson, Qixin Leng, Szu-Ting Chou, and Martin C. Woodle
13. Preparation of a Carrier to Achieve In Vivo Delivery of siRNA: The Example of Chitosan-Coated Poly(isobutylcyanoacrylate) Nanoparticles
Christine Vauthier
14. Monoclonal Antibody-Conjugated Dendritic Nanostructures for siRNA Delivery
Hitesh Kulhari, Ashok K. Jangid, and David J. Adams
15. Synthesis of Gold Nanoparticles for Gene Silencing
Claudia Tortiglione and Jesus M. de la Fuente
16. Design of Eco-Friendly Gold Nanoparticles for Cancer Treatment
Deep Pooja and Ramakrishna Sistla
17. 64Cu-Labeled Aptamers for Tumor-Targeted Radionuclide Delivery
Lei Kang, Zachary T. Rosenkrans, and Weibo Cai
18. Silencing PRDM14 via Oligonucleotide Therapeutics Suppresses Tumorigenicity and Metastasis of Breast Cancer
Hiroaki Taniguchi and Kohzoh Imai
19. Bio-Drug Suppresses Breast and Colorectal Cancer in Murine Models
Syed Sultan Beevi, Naveen Kumar Tangudu, Vinod Kumar Verma, and Lekha Dinesh Kumar
20. Combinatorial Nanoparticle Delivery of siRNA and Antineoplastics for Lung Cancer Treatment
Rebaz Ahmed, Narsireddy Amreddy, Anish Babu, Anupama Munshi, and Rajagopal Ramesh
21. Bioconjugated Gold Nanoparticles Enhance siRNA Delivery in Prostate Cancer Cells
Kamil Rahme, Jianfeng Guo, and Justin D. Holmes
22. Vaginal Suppositories with siRNA and Paclitaxel-Incorporated Solid Lipid Nanoparticles for Cervical Cancer: Preparation and In Vitro Evaluation
Gülay Büyükköroğlu, Behiye Şenel, and Evrim Yenilmez
23. The Use of Star Polymer Nanoparticles for the Delivery of siRNA to Mouse Orthotopic Pancreatic Tumor Models
Joshua A. McCarroll, George Sharbeen, Maria Kavallaris, and Phoebe A. Phillips
24. Microfluidic Assembly of siRNA-Loaded Micelleplexes for Tumor Targeting in an Orthotopic Model of Ovarian Cancer
Daniel P. Feldmann, Steven Jones, Kirk Douglas, Anthony F. Shields, and Olivia M. Merkel
25. Synthesis, Physico-Chemical, and Biological Evaluation of Spherical Nucleic Acids for RNAi-Based Therapy in Glioblastoma
Serena Tommasini-Ghelfi, Andrew Lee, Chad A. Mirkin, and Alexander H. Stegh
26. Folate-Decorated Polyamidoamine Dendrimer Nanoparticles for Head and Neck Cancer Gene Therapy
Leyuan Xu and Hu Yang
Includes cutting-edge techniques
Provides step-by-step detail essential for reproducible results
Contains key implementation advice from the experts
Date de parution : 08-2020
Ouvrage de 416 p.
17.8x25.4 cm
Date de parution : 05-2019
Ouvrage de 416 p.
17.8x25.4 cm