Risk Assessment for Human Metal Exposures Mode of Action and Kinetic Approaches
Auteurs : Nordberg Gunnar F., Fowler Bruce A.
Risk Assessment for Human Metal Exposures: Mode of Action and Kinetic Approaches examines the current principles of risk assessment in human metal exposures, with a focus on Mode of Action(MOA), Toxicokinetic and Toxicodynamic (TKTD) considerations, and computer models. Derived from the highly respected Handbook on the Toxicology of Metals, Fourth Edition (2014), the book summarizes principles and methods and provides examples of how MOA ?TKTD can be used. In addition, it presents tactics on how information generated by such methods can be confirmed by epidemiological data. Furthermore, it demonstrates how epidemiological data can be confirmed and evaluated by the examined models and considerations.
This resource uniquely integrates several important topics, such as risk assessment, characterization, management and communication?the classic risk assessment paradigm?with mode of action, TKTD, and epidemiology, all topics related to human exposure. Written by pioneers in the field, this book is an essential reference for researchers, students and technicians in toxicology and risk assessment.
- Covers fundamental risk assessment concerns for the effects of metals on human health
- Provides an easy-to-use structure to quickly locate specific methods
- Uses case studies to illustrate the methods and theories described
- Written to be understood by students, researchers and industry workers who need to conduct risk assessment in metals and human health
Date de parution : 08-2018
Ouvrage de 348 p.
15x22.8 cm
Thème de Risk Assessment for Human Metal Exposures :
Mots-clés :
Absorption; Acute toxicity; Additivity; ADI; Adverse outcome pathway (AOP)Biomarkers of effects; Adverse outcome pathway (AOP)Carcinogenicity; Adverse outcome pathways (AOPs)Critical effect; Age effects; Age-related sensitivities; Aluminum (Al)Arsenic (As)Cadmium (Cd)Cerium (Ce)Cobalt (Co)Gadolinium (Gd)Gallium (Ga)Indium (In)Lanthanum (La)Lead (Pb)Mercury (Hg)Nickel (Ni)Palladium (Pd)Platinum (Pt)Antagonism; AOPs; AROI; Arsenic; Biomarkers of exposure; Cadmium; Cause-and-effect; Chronic toxicity; Critical effects; Critical organ; Dose- response relationships; Dose-effect; Dose-response; DRI; Elemental interactions; environment interactions; Ethical issues; Ethical rules for research; ETMs; Exposome; Exposure assessments; Exposure biomonitoring; Food; Gene; Hill's considerations; ICOH; Inhalation; Lead; Mechanism of action; Mercury; Metal implants; Metal mixtures; Metal speciation; Metallic interactions; Metals; Mode of action (MOA)Reproductive toxicity; Mode of action (MOA)Target dose; Mode of action; Nanoparticles; No-observed-effect level (NOEL)Nonthreshold effects; PMTDI; Populations at risk; Populations at special risk; Prevention of adverse effects; PRI; PTWI; REACH; Research with animals; Research with humans; RfD; Risk assessment approaches; Risk assessment; Risk communication; Risk management; Scientific Committee on the Toxicology of Metals; Sensitive populations; Severity of effects; Synergy; Target organ distribution; TDI; Threshold effects; Toxic metals; Toxicokinetics; Toxicokinetic-toxicodynamic modeling (TKTD modeling)Types of risk; UL; Water