Radioactive Isotopes in Clinical Medicine and Research XXIII, 1999 Advances in Pharmacological Sciences Series

Radioactive Isotopes in Clinical Medicine and Research XXIII presents an update in the latest clinical research in nuclear medicine. It provides in-depth information on all areas of nuclear medicine. The chapters of this volume have been grouped into the following sections: Neurology / Psychiatry, Therapy, Radiopharmacology, Endocrinology / Thyroid, Oncology / Haematology, Clinical PET, Cardiology, Varia, Physics / Radiation Protection, World Wide Web / WWW demo. Special attention is paid to the virtual media for teaching, training, communication, quality control etc. Primarily intended for specialists in the nuclear medicine, this volume will also be of considerable interest to clinicians using diagnostic and therapeutic nuclear medicine procedures, including cardiologists, haematologists, neurologists, nephrologists, oncologists, pharmacologists, and psychiatrists.

The Badgastein Lecture.- The Challenge of the 21st Century.- Neurology, Psychiatry.- First Evaluation in Humans of [123I]PE21: A Selective Radioligand for Visualization of the Striatal Dopamine Transporter Density.- Comparison of Iodine-123 labelled Nor-ß-Cit and ß-Cit as Potential Radioligands for Serotonin Transporter Imaging.- Brain Serotonin and Dopamine Transporters in Depressive Children.- Prognostic Potential of Tc-99m-ECD-SPET within 6 Hours after Onset of Stroke Symptoms.- Brain Perfusion in Patients with Severe Sleep Apnea Syndrome (SAS) before and after n-CPAP-Therapy.- Therapy.- Radioimmunotherapy of Colorectal Cancer in Small Volume Disease: Preclinical Evaluation in Comparison To Equitoxic Chemotherapy and Preliminary Results of an Ongoing Phase-I/II Clinical Trial.- Radioimmunotherapy of Glioblastoma by Using I-131 and Y-90 Labeled Anti-tenascin Monoclonal Antibodies.- I-131-Lipiodol Therapy in Liver Neoplasms.- Individualized Dose Estimation for Sr-89 with the Use of Diagnostic Tc-99m MDP Bone Scintigraphy.- Rhenium-186-HEDP and Strontium-89-Chloride in Treatment of Metastatic Bone Pain.- The Development of Chromatographic 188W/188Re Generators for Therapy.- Radiopharmacology.- Evaluation of mRNA Targeting by Labeled Oligonucleotides for Tumor-Diagnosis.- Synthesis and Evaluation of [123I]-Iodoaminoglutethimide, a Ligand for Visualization of the Aromatase Enzyme by SPECT.- Comparative Analysis of Kinetic Models to Study Glucose Metabolism of the Brain.- Bone Scintigraphy and Palliative Therapy with Multibone Kit.- Pharmaosintigraphic Study of Localization in the G.I. Tract of Controlled Release Tablets Using 153Sm as Marker.- Endocrinology, Thyroid.- On the Use of Routine Preoperative Scintigraphy in Thyroid Carcinoma Patients.- The Value of HMPAO SPECT Scanning in Patients with Congenital Hypothyreosis.- Advanced Stage Thyroid Cancer — Treatment with Isotretinoin.- Is SPECT-Technique Necessary for Preoperative Diagnosis of Parathyroid Adenoma ?.- Oncology, Haematology.- Comparison of Interlesionally and Systemically Administered Radiolabelled Monoclonal Antibodies in Implanted Tumours.- Comparison of MRI and Somatostatin Receptor Scintigraphy (SRS) in Post-surgical Follow-up of Meningioma.- Comparison of Contrast Enhanced MRI, Tc-99m Hydroxymethylene Diphosphonate and Tc-99m Tetrofosmin Scintimammography in Patients with Suspicious Breast Lesions.- Neoadjuvant Treatment of Patients with Breast Cancer under Surveillance of 99mTc-Tetrofosmin Scintigraphy.- 99Tc-Furifosmin Uptake by Melanoma Cells.- Lymphoscintigraphy in Tumors of the Head and Neck Using a Double Tracer Technique.- Clinical PET.- Clinical Application of 18FDG-PET in the Assessment of Head and Neck Tumors.- The Role of FDG-PET and MIBI Investigations in the Restaging of Treated Patients with Malignant Lymphomas.- Assessment of Pulmonary Nodules and Colorectal Cancer Recurrences by FDG Scan on an”Ordinary“ Coincidence Gamma Camera (CDET).- Clinical Utility of 18FDG-PET with Molecular Coincidence Detection (MCD) and a Modified SPECT-Camera.- Deoxyglucose Uptake by Apoptosing and Proliferating Colonic Tumour Cells.- Cardiology.- Relation Between Viability, Improvement of LVEF and Heart Failure Symptoms after Revascularization.- Attenuation Corrected Tl-201 SPECT Using a Gd-153 Moving Line Source: Clinical Value and the Impact of Attenuation Correction on the Extent and Severity of Perfusion Abnormalities.- Correlation of EBCT and Tl-201-SPECT Scintigraphy in Patients with Coronary Heart Disease.- Influence of Right Ventricular Stimulation Site on Left Ventricular Function in a Trial Synchronous Pacing.- Varia.- 153Sm-EDTMP for Pain Relief in Malignant and Benign Bone and Joint Diseases.- Tc-99m-Tetrofosmin SPECT Scintigraphy in the Post-operative Follow-up of Microvascular Anastomosed Flaps in Facial Reconstruction.- Long-Term Follow-up Study of Gastric Emptying and Helicobacter Pylori Eradication among Patients with Functional Dyspepsia.- The Value of Renal Scintigraphy under Controlled Diuresis in Children with Hydronephrosis.- Assessment of Brain Perfusion by ECD-Tc99m SPET in Rett Syndrome.- Detection of Inflammatory Bowel Diseases in Children with 99mTc Anti- granulocyte Mab (BW 250/183) Scintigraphy.- Physics, Radiation Protection.- Attenuation Correction in PET Using Cs-137 Singles Transmission and Iterative Reconstruction.- Optimization of Acquisition Protocols Based on 18F-FDG Phantom Studies Using a Dual Head SPECT Camera in Coincidence Mode.- Radiation Protection in I-131-Lipiodol Therapy in Liver Neoplasms.- Radiation Exposure Deriving from Patients Treated with 165Dy-Ferric Hydroxide.- Reconstruction of SPECT Data Using an Artificial Neural Network.- World Wide Web; WWW Demo.- The Use of Internet as a Mode of Delivery for Nuclear Medicine Postgraduate Education.- Two Years Experience with an Exclusively Internet-Based Virtual Lecture for Medical Students and Postgraduates.- Tele Nuclear Medicine on the World Wide Web.- A Java-Enhanced Nuclear Medicine Teaching File.- Emerald — European Medical Radiation Learning Development — for Vocational Training and Interactive Learning on World Wide Web — Nuclear Medicine Training Module.- Java-Based Remote Viewing Station for Nuclear Medicine Images.- Poster Session I.- Preoperative Determination of Stroke Risk with ECD SPECT Before Therapeutic Carotid Artery Occlusion.- Asymmetry of the Dopaminergic System in Schizophrenic Patients.- Blood Flow Changes in Cerebral and Cerebellum Cortex in Obsessive-Compulsive Disorder Patients Evaluated with ECD-Tc99m SPET.- 99mTc-HMPAO SPECT in Borderline Conditions Related to the Aging Brain.- Quantitative Brain Perfusion Analysis in Hypertension During Rest and Exercise Technetium-99M-HMPAO Single-Photon Emission Computed Tomography.- Long Term Side Effects After High Dose Radioiodine Therapy in Thyroid Carcinoma Patients.- Intraarterial I-131-MIBG Treatment — Clinical and Dosimetric Results.- Development of 166Ho-Ho, Fe-Hydroxide (HFH) and 166Ho-Hydroxyapatite (HA) for Radioembolization Therapy of Liver Malignancies.- Possible Use of 11C-Labeled 8-(3-Chlorostyryl) Caffeine (CSC) Mapping A2A Adenosine Receptors in the CNS and Myocardium.- In-Vitro Studies on the Usefulness of 99mTc-Tetrofosmin for Sarcoma Detection.- The Effect of Metabolic Degradation on Radiotracer Design.- Investigation of Rhenium Complex Formation for Development of Bone-Seeking Kit for 188-W/188-Re Generator.- 199TL-Diethyldithiocarbamate-SPECT in Diagnosis of Brachiocephalic Arteries Atherosclerosis.- Vincristine Effect on the Distribution of Radiopharmaceuticals in Mice.- Poster Session II.- Assessment of Left Ventricular Ejection Fraction Using Radionuclide Ventriculography in Patients with Acromegaly.- Technetium-99m-Pertechnetate Scintigraphy in Small Thyroid Nodules.- The Imaging of Thyroid Tumors: MRI v. Radionuclide Scintigraphy and Ultrasound.- Pulmonary Tuberculosis and Its Therapy’ s Effect on Thyroid Function. A Short-Term Prospective Study.- Serum Total T3-, T4-and TSH-Concentrations in Vietnamese Newborn Babies Living in Endemic Nongoitrous (ENR) and In Endemic Goitrous (EGR) Regions During the First Seven Days of Life.- High Activity Radioiodine Therapy for Advanced Differentiated Thyroid Carcinoma: Efficacy and Morbidity.- Posttherapeutic Care of Patients with Medullary Thyroid Carcinoma-Diagnostic Value of In-Vitro-Parameters and Imaging.- Improved Negative Predictive Value of Mammoscintigraphy in Patients with Breast Cancer by Means of a”Malignancy Index“.- Quantitative Tc-99m Tetrofosmin Scintigraphy in the Differentiation of Malignant from Benign Breast Masses.- The Relationship Between Proliferation and Deoxyglucose Uptake by Breast Tumour Cells.- Potential Role of Whole-Body 18FDG-PET in the Routine Staging of Malignant Melanoma.- The Possible Place of FDG-PET Investigations in the Differential Diagnosis of Focal Pancreatic Lesions.- FDG PET in the Follow-Up of Patients with Differentiated Thyroid Cancer.- Aprotinin 99mTc Myocardial Scan: Risk Stratification of Cardiac Events in Patients with AL/ATTR Amyloidosis.- Disturbed Myocardial Energy Metabolism in Patients with Nontransmural Chronic Myocardial Infarction.- Quantitative, Multivariate Analysis — Based Assessment of MIBI Planar Heart Perfusion Studies.- Poster Session III.- Detection of Fistulae in Crohn’s Patients with Immunoscintigraphy (JS).- Immunoradiometric Assay of Total PSA, Free PSA and PSA Ratio Calculation in Prostatic Cancer (Pca) Diagnosis.- 3-D-Imaging and Volume Mathematics versus Common Static Imaging in Combined Inhalation/Perfusion Lung Scintigraphy.- Investigation of Plasminogen Activator Effects on Progressive Ischemia into the Tissue Adjacent the Burn Injury by Tc-99m MIBI Scintigraphy and Autoradiography in an Experimental Local Burn Model.- Improvement in SPECT Imaging and Reduction of the Absorbed Dose Using an Additional Compton Energy Window For l8FDG.- Usable Countrates for a Commercially Available Dual-Head-PET-System.- Internal Exposure to Relatives of Radioiodine Therapy Patients from 1-131 Inhalation at Home.- The Usage of Gated SPECT in Lung Scintigraphy Phantom Studies and Clinical Results.- The Department of Nuclear Medicine, Szeged, on the Internet.- Nuclear Medicine Image Data Easy Transfer Via E-Mail.- Talk to Your Patients Via Internet! Patient Information in a Community Network.- Free Papers.- Factors Influencing Myocardial Uptake of MIBG In-Vitro.- Binding Studies with Oxidized and Glycated 125I-LDL to Detect Macrophage Scavenger-and Age-Receptors in Atherosclerotic Lesions.- Auger and Conversion Electron Therapy with In-111 Pentetreotide in Hepatocellular Carcinoma.- Author Index.