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Physiologically Based Pharmacokinetic (PBPK) Modeling Methods and Applications in Toxicology and Risk Assessment

Langue : Anglais

Coordonnateurs : Fisher Jeffrey W., Gearhart Jeffery M., Lin Zhoumeng

Couverture de l’ouvrage Physiologically Based Pharmacokinetic (PBPK) Modeling

Physiologically Based Pharmacokinetic (PBPK) Modeling: Methods and Applications in Toxicology and Risk Assessment presents foundational principles, advanced techniques and applications of PBPK modeling. Contributions from experts in PBPK modeling cover topics such as pharmacokinetic principles, classical physiological models, the application of physiological models for dose-response and risk assessment, the use of in vitro information, and in silico methods. With end-of-chapter exercises that allow readers to practice and learn the skills associated with PBPK modeling, dose-response, and its applications to safety and risk assessments, this book is a foundational resource that provides practical coverage of PBPK modeling for graduate students, academics, researchers, and more.

Foreword Melvin Andersen

Preface Jeffrey W. Fisher, Zhoumeng Lin and Jeffery M. Gearhart

1. A history and recent efforts of selected physiologically based pharmacokinetic modeling topics Zhoumeng Lin and Jeffrey W. Fisher

2. Introduction to classical pharmacokinetics Shruti V. Kabadi and Zhoumeng Lin

3. Fundamentals of physiologically based pharmacokinetic modeling Jeff Fisher, Xiaoxia Yang, Darshan Mehta, Conrad Housand and Zhoumeng Lin

4. Physiologically based pharmacokinetic modeling software C.E. Hack, A.Y. Efremenko, S.N. Pendse, C.A. Ellison, A. Najjar, N. Hewitt, A. Schepky and H.J. Clewell III

5. Chemical absorption and writing code for portals of entry Jeffrey W. Fisher, Jeffery M. Gearhart, Jerry L. Campbell Jr and Darshan Mehta

6. Physiologically based pharmacokinetic model: distribution processes Christopher Ruark

7. Metabolism and physiologically based pharmacokinetic models Jeffrey W. Fisher, Jerry L. Campbell Jr. and Zhoumeng Lin

8. Physiologically based pharmacokinetic model: excretion via urine, feces, and breath Sami Haddad and Andy Nong

9. Sensitivity and Monte Carlo analysis techniques and their use in uncertainty, variability, and population analysis Tammie R. Covington and Jeffery M. Gearhart

10. Physiologically based pharmacokinetic model calibration, evaluation, and performance assessment Zhoumeng Lin, Yi-Hsien Cheng, Wei-Chun Chou and Miao Li

11. Examples of physiologically based pharmacokinetic modeling applied to risk assessment Lisa M. Sweeney and Jeffery M. Gearhart

12. Physiologically based pharmacokinetic models to support modernized chemical safety assessment Miyoung Yoon

Faculty, researchers, post docs, and graduate students in the fields of toxicology, pharmacology, environmental health, epidemiology, risk assessment biostatistics, data analytics, and bioinformatics as well as working professionals, consultants, state and federal public health agencies, European health agencies (EU, trade groups)

Dr. Jeffrey Fisher is a research toxicologist with the U.S. Food and Drug Administration, National Center for Toxicological Research. He was formerly a Professor in the Department of Environmental Health Science, College of Public Health at the University of Georgia (UGA). He joined the University of Georgia in 2000 and served as Department Head of the Department of Environmental Health Sciences from 2000 to 2006 and Director of the Interdisciplinary Toxicology Program at UGA from 2006-2010. He spent most of his career at the Toxicology Laboratory, Wright Patterson AFB, where he was Principal Investigator and Senior Scientist in the Toxics Hazards Division and Technical Advisor for the Operational Toxicology Branch. Dr. Fisher has published over 170 papers on pharmacokinetics and PBPK modeling in laboratory animals and humans. He has served on several national panels and advisory boards for the DoD, ATSDR, USEPA and non-profit organizations. He was a U.S. delegate for the North Atlantic Treaty Organization. Dr. Fisher served on the International Life Sciences Institute Steering Committee, which evaluated chloroform and dichloroacetic acid using EPA-proposed Carcinogen Risk Guidelines. He is Past President of the Biological Modeling Specialty Section of the Society of Toxicology, reviewer for several toxicology journals, and was Co-Principal Investigator on a National Institutes of Health (NIH)-supported workshop on Mathematical Modeling at the University of Georgia in the fall of 2003. He was a member of the National Academy of Sciences subcommittee on Acute Exposure Guideline Levels (AEGLs) from 2004-2010 and Science Advisory Board for the US EPA (2007-2010). He is a fellow of the Academy of Toxicological Sciences and an associate editor for Toxicological Sciences. Dr. Fisher has a B.S. degree in biology from the University of Nebraska at Kearney, a M.S. degree in biology from Wright State University, and a Ph.D. in Zoology/Toxicology from Miami University.
Dr.
  • Provides end-of-chapter exercises to teach hands-on computational tools used in toxicology
  • Supplies computer code and explanations and includes examples of applied models used in regulatory toxicology and research
  • Authored by expert editors and contributors who are among the best PBPK modelers in the world

Date de parution :

Ouvrage de 346 p.

19x23.3 cm

Disponible chez l'éditeur (délai d'approvisionnement : 14 jours).

170,55 €

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