Pharmacotherapeutic Botanicals for Cancer Chemoprevention , 1st ed. 2020

The book presents a comprehensive and up-to-date overview of phytochemicals as efficient cancer therapeutics. Over the last few decades there has been a paradigm shift from conventional cancer therapeutic approaches to alternative and complementary medicinal approaches especially using phytoconstituents from natural products. As such, the book provides an in-depth understanding of phytochemicals targeting diverse signaling pathways involved in cancer along with the evaluation of the cancer modulatory effects of phytochemicals. It also highlights the potential modulatory effect of single nucleotide polymorphisms (SNPs) on the cancer-associated cellular pathways and their interactions with the phytochemicals. Further, it analyzes the drug delivery methods, bioavailability of active components of botanicals, and toxicity of phytochemicals. Lastly, the book elucidates the 3D cell culture and animal models systems to analyze the beneficial effects of phytochemicals in cancer.

Chapter 1. Phytochemicals in Cancer Chemoprevention: A Brief Perspective.- Chapter 2. Phytochemicals in Modulating Signalling Cascades in Cancer Cells.- Chapter 3. Diverse cancer therapeutic interactions: complexities in cancer management.- Chapter 4. Natural Products as Chemosensitizers for Adjunct Therapy in Cancer Management.- Chapter 5. Dietary phytochemicals as epigenetic modulators in cancer prevention: Emerging research trends, gaps, and future perspectives.- Chapter 6. Modulation of Cancer Cell Metabolism and Microenvironment by Phytochemicals.- Chapter 7. Role of Nutrigenetics and Nutrigenomics in Cancer Chemoprevention.- Chapter 8. Nano-delivery carriers for Enhanced Bioavailability of Antitumor Phytochemicals.- Chapter 9. Biphasic Effects of Phytochemicals and their Relevance to Cancer Therapeutics.- Chapter 10. Potential Pharmacotherapeutic Phytochemicals from Zingiberaceae for Cancer Prevention.- Chapter 11. 3 Dimensional Cell Culture Techniques in Cancer Research.- Chapter 12. Animal Models Systems of Cancer for Preclinical Trials.- Chapter 13. Cancer Chemoprevention by Natural Plant Products and Their Derivatives: Clinical Trials.

Dr. Manish Kumar is an Assistant Professor of Botany at S.D. College, Barnala, Punjab, India. He holds M.Sc. (Hons.), M.Phil. & Ph.D. in Botany from Guru Nanak Dev University, Punjab, India. He has over 3 years of teaching and 9 years of research experience in cancer chemoprevention, cancer cell therapeutics, environmental mutagenesis, and medicinal plants. He has published more than 35 research articles in journals and books of international repute with a cumulative impact factor of more than 35. He is an editorial board member of various national and international journals.

Dr. Praveen Kumar is currently working as a Postdoctoral Researcher at the Technion, Israel Institute of Technology Haifa, Israel. He has completed his Ph.D. from the National Institute of Immunology, New Delhi, India. He has over 9 years of research experience in molecular cell biology and cancer metabolism. His specializations include cancer cell metabolomics, cell cycle metabolomics, and metabolomics based drug screening.

Reviews the efficacy of phytochemicals as the cancer chemopreventive and treatment agents

provides mechanistic insights into the pharmacological effects of these phytochemicals

Explores phytochemicals as the epigenetic modulators in cancer cells

Analyzes the drug delivery methods, bioavailability, and toxicity of phytochemicals