Perinatal Stem Cells Research and Therapy
Coordonnateurs : Atala Anthony, Cetrulo Kyle J., Taghizadeh Rouzbeh R., Cetrulo Curtis L, Murphy Sean
Perinatal Stem Cells provides researchers and clinicians with a comprehensive description of the current clinical and pre-clinical applications of stem cells derived from perinatal sources, such as amniotic fluid, placenta and placental membranes, the umbilical cord and Wharton?s jelly. It's compiled by leading experts in the field, offering readers detailed insights into sources of perinatal stem cells and their potential for disease treatment. Therapeutic applications of perinatal stem cells include the treatment of in utero and pregnancy related diseases, cardiac disease, liver disease, pulmonary disease, inflammatory diseases, for hematopoietic regeneration, and for neural protection after stroke or traumatic brain injury.
In addition, the rapid advance in clinical translation and commercialization of perinatal stem cell therapies is highlighted in a section on Clinical and Industry Perspective which provides insight into the new opportunities and challenges involved in this novel and exciting industry.
Section I. Amniotic Fluid-Derived Stem Cells
1. In utero therapy for congenital disorders using amniotic fluid stem cells
2. The Amniotic Fluid Stem Cell Secretome: at the Heart of Regeneration
3. Transplantation of Amniotic Fluid-Derived Neural Stem Cells
4. Stroke therapy: the potential of amniotic fluid-derived stem cells
5. Vascular formation by human perinatal stem cells
6. Amniotic Fluid Stem Cells for Kidney Regeneration
Section II. Placental and Placental Membrane-Derived Stem Cells
7. Placental mesenchymal stem cells for cellular cardiomyoplasty
8. Heterogeneous functions of perinatal mesenchymal stromal cells require a preselection before their banking for clinical use
9. Defining the fetal stem cell niche in the human placenta
10. Banking placental tissue hematopoietic stem cells and mesenchymal stem cells for clinical use
11. Immuno-modulatory mechanisms of placental stem cells
12. Amnion Membrane Allograft for Regenerative Medicine
13. Perinatal cells and biomaterials for wound healing
14. Placental Stem Cells
15. Therapeutic Effect of Extracellular Vesicles Derived from Adult/Perinatal Human Mesenchymal Stem Cells
Section III. Umbilical Cord-Derived Cells
16. Ex-vivo Expansion of Cord Blood Stem Cells
17. Cord Blood Transplantation: Therapeutic Use of Perinatal Stem Cells
18. Autologous Human Cord Blood as a Treatment for Traumatic Brain Injury in Children
19. Phenotypic and Functional Characterization Perinatal Stem Cells Isolated from Umbilical Cord Tissue
20. Mesenchymal stromal cells from Wharton’s jelly (WJ-MSCs): coupling their hidden differentiative program with their frank immunomodulatory phenotype
21. Regeneration of ischemic cardiovascular damage using Jelly Wharton as an unlimited source of therapeutic stem cells
22. Phenotype with Focused Paracrine Fractions: Effecting Future Phenotype with Focused Paracrine Fractions
Section IV. Clinical and Industry Perspective
23. Clinical Translation of Perinatal Stem Cell Therapy
24. Current Clinical Trials utilizing Perinatal Stem Cells – A Review
25. Review Of Processing Technology and Techniques for Perinatal Stem Cells Banking And Clinical Applications
26. Clinical Development And Commercialization Of Placenta-Derived Cell Therapy
27. How the patent landscape has changed
28. The Need for Better Assays to Predict the Effectiveness of Tissue Stem Cell Treatments
Dr. Atala has led or served several national professional and government committees, including the National Institutes of Health working group on Cells and Developmental Biology, the National Institutes of Health Bioengineering Consortium, and the National Cancer Institute’s Advisory Board. He is a founding member of the Tissue Engineering Society, Regenerative Medicine Foundation, Regenerative Medicine Manufacturing Innovation Consortium, Regenerative Medicine Development Organization, and Regenerative Medicine Manufacturing Society.
- Explores current clinical and pre-clinical application of stem cells derived from perinatal sources
- Offers detailed insight into sources of perinatal stem cells and their potential for disease treatment
- Discusses progress in the manufacturing, banking and clinical translation of perinatal stem cells
- Edited by a world-renowned team to present a complete story of the development and promise of perinatal stem cells
Date de parution : 06-2018
Ouvrage de 418 p.
21.4x27.6 cm
