Pediatric Oncologic Pharmacy, 1st ed. 2019 A Complete Guide to Practice

1.1   The pharmacist and chemotherapy in children

1.3   Pharmacist in rheumatology area: chemotherapy for rheumatic children

1.4   Differences in sectors of manipulation of chemotherapy around the world

1.5   Chemotherapy in children

1.6   Chemotherapy in neonates and infants

2.       Diseases in pediatric hemato/ oncology area and treatments

2.1   Acute lymphoid leukemia

2.2   Acute myeloid leukemia

2.3   Chronic myeloid leukemia

2.4   Hodgkin lymphoma

2.5   Non-Hodgkin lymphoma

2.6   Osteosarcoma

2.7   Central nervous system tumors

2.8   Retinoblastoma

2.9   Wilms tumor

2.10 Burkitt’s lymphoma

2.11 Hepatoblastoma

2.12 Congenital tumors

3.       Diseases in rheumatology and their treatment with chemotherapy

3.1   Sometimes symptoms of rheumatic diseases is, actually, first sign of pediatric cancer

3.2   Rheumatic disease in children

3.3   Introduction

3.3.1 Pediatric Lupus

3.3.2 Pediatric idiopathic arthritis

3.3.3 Pediatric dermatomyositis

3.3.4 Pediatric  scleroderma

3.3.5 Pediatric Kawasaki disease

3.3.6 Pediatric mixed connective tissue disease

3.3.7 Pediatric fibromyalgia

3.3.8 Rheumatic diseases in neonates and infants

4.       Pharmacokinetics and pharmacodynamics of chemotherapy in children — The used drugs

4.1   Brentuximab

4.2   Busulfan

4.3   Carboplatin

4.4   Carmustine

4.5   Cisplatin

4.6   Cyclophosphamide

4.7   Cytarabine

4.8   Dacarbazine

4.9   Daunorubicin

4.10    Docetaxel

4.11    Doxorubicin

4.12    Etoposide

4.13    Gentamicin

4.14    Hydroxyurea

4.15    Idarubicin

4.16    Ifosfamide

4.17    Imatinib

4.18    Irinotecan

4.19    Lomustine

4.20    L-asparaginase

4.21    Methotrexate

4.22    Paclitaxel

4.23    Trans retinoic acid

4.24    Vinblastine

4.25    Vincristine

4.26    Vinorelbine

5.       Physical-chemical compatibility of drugs used in chemotherapy for children

5.1   Brentuximab

5.2   Busulfan

5.3   Carboplatin

5.4   Carmustine

5.5   Cisplatin

5.6   Cyclophosphamide

5.7   Cytarabine

5.8   Dacarbazine

5.9   Daunorubicin

5.10    Docetaxel

5.11    Doxorubicin

5.12    Etoposide

5.13    Gentamicin

5.14    Idarubicin

5.15    Ifosfamide

5.16    Irinotecan

5.17    Lomustine

5.18    L-asparaginase

5.19    Methotrexate

5.20    Paclitaxel

5.21    Vinblastine

5.22    Vincristine

5.23    Vinorelbine

6.       Drug Interactions involving chemotherapy for children

 (This chapter will provide tables with very practical information of drug interactions, resumed mechanism of each interaction and, in case of undesirable interactions, alternatives to avoid them).

7.       Prescription analysis

 (This chapter will provide information about prescription analysis of protocols, doses, physical-chemical compatibilities, drug interactions, patients follow-up, laboratory tests and other pertinent subjects). 

8.       Handling pediatric chemotherapy

8.1   Intravenous

8.3   Subcutaneous

8.4   For use in surgery

9.       Handling pediatric intrathecal drugs

(This is a very important topic, given that intrathecal chemotherapy is largely used in pediatrics and it has many peculiarities).

10.       Handling pediatric extemporaneous oral solutions with chemotherapy

 (This is a very important topic aimed to pediatric oncology. Sometimes patients are neonates, infants or simply cannot swallow. This chapter will provide pharmacotechnical complete information to convert tablets into syrup, as shelf life, how to prepare each drug and other important subjects). 

11.   Administration of a pediatric oncology pharmacy: from the purchase of the drugs to the dispensation

(All administration subjects that pharmacists need to know to work in a Pediatric Oncology Pharmacy, as selective inventory control/ ABC curve, curve XYZ, selection of suppliers, lot tracking, traceability, receiving drugs, computerized system and reports). 

12.   Chemotherapy for pediatric stem cell transplantation

 (Pharmacists even more handle chemotherapy for stem cell transplantation in children. Chemotherapy for stem cell transplantation varies a lot from that used for cancer and tumors treatment. This chapter will provide all information needed for a safety handling of these drugs for stem cell transplantation).

13.   Biosafety for pharmacists and technical team in pediatric chemotherapy area

 (This chapter will provide information about safety for pharmacists, appropriate equipment, necessary examinations, risks and other pertinent subjects).

14.   Supportive therapy for pediatric patients receiving treatment with chemotherapy

14.1  Pediatric pain and the pharmacist

14.2    Pediatric nausea and vomiting and the pharmacist

15.   Pediatric clinical pharmacy involving chemotherapy

16.   Pediatric pharmaceutical care involving chemotherapy

17.  Appendix

17.1 Body Surface Area

17.2 Tumor Lysis Syndrome

18.   References

Author of Springer books “Chemotherapy in Neonates and Infants — Pharmacological oncology for children under 1 year old” (2018) and “Drug Therapy and Interactions in Pediatric Oncology — A Pocket Guide” (2017). Pediatric Oncology Pharmacist with extensive experience with Chemotherapy in Children. Oncological Hospital Pharmacy Specialist; Planning and Business Management Specialist. Extensive experience in hospitals and clinics, with Pharmacy, Drug Interactions, Pediatrics, Oncology, Hematology, Neonatology, Intensive Health Care and Infectology. Academic experience in Pharmacy, Pediatrics, Oncology and Hematology; teaching for specialists as pharmacists, physicians and nurses. Writer of children's books about cancer.

Unique, first-of-its-kind title not only for clinical pediatric oncologic pharmacists but also for hemato/oncology pharmacists, clinical pharmacists, pharmacists who work in pharmaceutical care for pediatric oncology patients, rheumatology pharmacists, pharmaceutical residents and researchers

Comprehensive, covering a wide range of topics essential to daily practice

Easy to read, offering essential and practical information in a point-of-care format