Pediatric Obesity, 2010 Etiology, Pathogenesis, and Treatment Contemporary Endocrinology Series

Childhood obesity and its co-morbidities -- including type 2 diabetes, hypertension, dyslipidemia, sleep apnea, and fatty liver disease -- have seen striking increases in recent years. Despite a wealth of investigation, there is considerable controversy regarding the etiology of childhood obesity and the optimal approaches for prevention and treatment. Pediatric Obesity: Etiology, Pathogenesis, and Treatment addresses the controversy with a range of features that make it a unique resource for those who care for obese children and their families. Written from a perspective that is international in scope, the distinguished authors re-assess the roles of genetic and environmental factors in the pathogenesis of childhood obesity and critically review new studies of the effects of lifestyle, pharmacologic, and surgical interventions. The evidence-based approach of Pediatric Obesity: Etiology, Pathogenesis, and Treatment provides a comprehensive and invaluable guide for all healthcare providers concerned with the evaluation and care of children with nutritional and metabolic disease and with the societal implications of the obesity epidemic.

The obesity epidemic: a global perspective 1. Global dynamics in childhood obesity: reflections on a life of work in the field: Barry Popkin The neurendocrine perspective: the control of appetite and energy expenditure 2. The neuroendocrine control of energy balance: Robert Lustig The genetics of childhood obesity 3. Monogenic obesity: David Meyre and Philippe Froguel 4. Syndromic obesity: Andrea Haqq 5. Polygenic obesity: Anke Hinney and Johannes Hebebrand 6. Racial differences in childhood obesity: pathogenesis and complications: Jamie Haidet, C. Demirci and Silva Arslanian Pre- and perinatal determinants of childhood obesity: 7. Maternal determinants of childhood obesity: weight gain, smoking, and breast feeding. Katherine Y. Woycik and Elizabeth Mayer-Davis 8. Intrauterine growth retardation: Ken Ong 9. Gestational diabetes: Dana Dabelea The roles of diet and energy expenditure in obesity pathogenesis 10. The role of diet: Laura Johnson and Susan Jebb 11. The role of Non-Exercise Activity Thermogenesis (NEAT): Lorraine Lanningham-Foster and James Levine Metabolic complications of childhood obesity 12. Childhood obesity and the regulation of growth, thyroid function, sexual development, and calcium homeostasis: Michael Freemark 13. Pathogenesis of insulin resistance and glucose intolerance in childhood obesity: Ram Weiss and Sonia Caprio 14. Pathogenesis and management of dyslipidemia in obese children: Brian McCrindle 15. Fatty liver disease: Anna Alisi, Melania Manco, Rita Devito, and Valerio Nobili 16. Pathogenesis of hypertension and renal disease in obesity: Tracy Hunley and Valentina Kon 17. Sleep-disordered breathing and sleep duration in childhood obesity: SL Verhulst 18. The long-term metabolic complications of childhood obesity: Charles J. Glueck, John A. Morrison, Muhammad Umar, Naila Goldenberg, and Ping Wang 19. Childhood obesity, atherogenesis, and adult cardiovascular disease: Henry McGill. C Alex McMahan and S Gidding Treatment of childhood obesity: lifestyle intervention 20. Family-based lifestyle and dietary counseling: Denise Wilfley, Anna Vannucci and Emily K. White 21. Exercise and childhood obesity: Alon Eliakim and Dan Nemet 22. School- and community-based interventions: Joel Gittelsohn and Sohyun Park Management of obesity with complications: pharmacotherapy and bariatric surgery 23. Pharmacotherapy of childhood obesity and pre-diabetes: Michael Freemark 24. Pathogenesis and management of adiposity and insulin resistance in the polycystic ovary syndrome: Stephen Franks and Jalini Joharatnam 25. Obesity and metabolic dysfunction in the child with a major behavioral disorder: atypical antipsychotics: Lauren Shin and David Henderson 26. Pathogenesis and treatment of hypothalamic obesity: Robert Lustig 27. Bariatric surgery in adolescents: Basil Yurcisin and Eric Demaria Challenges to long-term success: 28. Neuroendocrine and metabolic adaptations that facilitate weight re-gain. Ronald Lechan and Csaba Fekete 29. The socio-cultural context for obesity prevention and treatment in children and adolescents: influences of ethnicity and gender. Shiriki Kumanyika, Joanna Holsten, Elizabeth Proust Parks The future of childhood obesity in the global marketplace: 30. The marketing and distribution of fast food: Michelle Christian and Gary Gereffi 31. Local and national policy-based interventions: Marlene Schwartz and Kelly Brownell Appendix