Nucleic Acid Nanotheranostics Biomedical Applications Micro and Nano Technologies Series
Coordonnateurs : Filice Marco, Ruiz-Cabello Jesús
Nucleic Acid Nanotheranostics: Biomedical Applications offers a comprehensive overview of improvements and new trends in fabrication of nanostructures as theranostic multifunctional carriers in gene therapy. With a strong focus on medical applications (comprising diagnosis, therapy and imaging), the book also examines gene therapy in an individual patient?s cells or tissues to treat genetic diseases. Sections cover Biomedical and Diagnostic applications of Nucleic Acids, Biologic and Synthetic Advanced Nanostructures for nucleic acid delivery, and important considerations of nanomedicine. This book is a valuable guide for materials scientists, physicians, chemists and engineers, but is also ideal for clinicians wishing to expand their knowledge.
1. Therapeutic oligonucleotides against cancer: Recent approaches and new perspectives 2. Small interfering RNA-mediated silencing of ribophorin II (RPN2) gene: The way forward for the treatment of malignant breast cancer 3. Non-coding RNAs in cardiovascular disease 4 MicroRNAs in respiratory diseases 5. State of the art and future direction for the analysis of cell-free circulating DNA 6. Aptamer-based strategies for diagnosis 7. Viral Vectors for Treatment of Human Disease: Therapeutic and Manufacturing Challenges 8. Nonviral nucleic acid therapy: Peptiplexes 9. Controlling Protein Expression by Delivery of RNA Therapeutics Using Lipid Nanoparticles 10. Advanced Polymers for Nonviral Gene Delivery 11. Nonviral Gene Therapy: Design and Application of Inorganic Nanoplexes 12. Extracellular vesicles as a novel nanocarriers for therapeutic delivery 13. Nanocarrier-based Gene therapy Imaging Strategies 14. The state-of-art of investigational and approved nanomedicine products for nucleic acid delivery
Materials Scientists and Biochemists, Biomedical engineers, Clinicians, Pharmaceutical chemists, and researchers working on nanomaterials, especially those with healthcare applications
His research work is mainly focused on the multidisciplinary-based design and creation of nanomaterials/biomacromolecules artificial hybrids showing highly improved or de novo biological properties. These highly engineered chimers are achieved by integrating a wide set of different disciplines such as surface and colloids chemistry, nanotechnology, bioorganic and bioinorganic chemistry, enzymology, bioinformatics, biocatalysis, site-specific modification, oriented immobilization of biomacromolecules, molecular imaging or biochemistry. The as prepared artificial nanobiohybrids have shown a wide application scope mainly in advanced synthesis and catalysis, development of novel ultrasensitive molecular diagnostics and nanomedicine (theranosis of cardiovascular, pulmonary, cancer and immune-based diseases).
Jesús Ruiz-Cabello is Ikerbasque Professor and Research , head of the Molecular and Functional Biomarkers group of the CIC Biomagune in San Sebastian/Donostia, and Scientific Assistant Director of the Spanish Biomedical Network of Research in Respiratory Diseases (CIBERES) depending of the National Institute o
- Provides a unique source of knowledge (theoretical as well as practical) on nanotheranostic materials for gene therapy at all levels and related scientific areas
- Covers the pros and cons related to viral and nanomaterial-based delivery of nucleic acids in terms of biosafety, carrier selection, synthesis and bioimaging
- Presents the only book to include an analysis of nanoformulations approved for clinical use
Date de parution : 02-2019
Ouvrage de 491 p.
19x23.3 cm
Thèmes de Nucleic Acid Nanotheranostics :
Mots-clés :
Antisense; Aptamers; Aptasensors; BAPCs; Biomarkers; Breast cancer; Cancer; Cancer therapy; Carbon nanotubes; Cardiovascular development; Cardiovascular disease; Catalytic oligonucleotides; Cell penetrating peptide; Circulating cell-free DNA (cfDNA); Circulating tumor DNA (ctDNA); Clinical evaluation; Clinical translation; Clinical trials; Combination therapy; CT imaging; Delivery; DNA; DNA delivery; DNA PAINT; DNAzymes; Drug delivery system; Drugs; Efficiency; EMA; Exosome; Expression; Extracellular vesicle; FDA; FRET; Gene therapy; Genetic disease; Gold nanoparticles; Graphene; In vitro and in vivo results; Infectious disease; Inorganic nanoparticles; Inorganic nanoplexes design; KeywordExtracellular vesicles; Lipid nanoparticle (LNP); Liquid biopsy; Long noncoding RNAs; Lung; Manufacturing; MicroRNAs; Microvesicle; miRNA; Molecular imaging; MR imaging; mRNA; Nanocarrier; Nanomedicine; Nanoparticles; Noncoding RNAs; Nonviral gene vector; Nonviral vectors; Nucleic acid delivery; Nucleic acids; Oligonucleotides; Oncolytic virus; PAMAM; PEI; Peptiplex; Peptosomes; PLL; Preclinical studies; Predictive biomarker; Prognostic biomarker; Quantum dots; Reporter genes; Respiratory diseases; Ribozymes; RNA; RNA therapy; RPN2; Safety; SELEX; siRNA; Small or short noncoding RNAs; Superparamagnetic iron oxide nanoparticles; Theranosis; Theranostics; Therapeutic tools; Therapeutics; Therapy; Ultrasound imaging; Vaccine; Viral vector; Virus engineering
