Novel Drug Delivery Systems for Phytoconstituents

Novel Drug Delivery Systems for Phytoconstituents discusses general principles of drug targeting, construction material and technological concerns of different phytoconstituent in delivery systems. It focuses on the development of novel herbal formulations and summarizes their method of preparation, type of active ingredients, route of administration, biological activity and their applications. It dicusses therapeutic activities of plant derived chemicals, their limitations in clinical applications and novel drug delivery solutions to overcome them to provide better therapeutic effects with controlled and targeted drug delivery.

• Focus on drug delivery of phytomolecules
• Act as bridge between natural product scientist and clinical doctors
• Discusses mechanism of poor bioavailability of herbal molecules
• Increases awareness towards phytochemical efficacy
• Summarizes efficient novel delivery systems-based formulations.

It extensively covers the applications of novel drug delivery systems including polymeric nanoparticles, solid lipid nanoparticles, nanostructured lipid capsules, liposomes, phytosomes, microsphere, transferosomes, and ethosomes. Some chapters are especially focused on anticancer phytodrugs, silymarin, andrographolide, berberine, and curcumin delivery with special emphasis on their application.

Contents

Preface ..................................................................................................................................................... vii

Editors ....................................................................................................................................................... ix

Contributors .............................................................................................................................................. xi

Section I Drug Delivery Systems

1. Novel Drug Delivery Systems for Phytoconstituents: Current and Future Prospects .............. 3

Vikas Sharma, Madhu Gupta, Durgesh Nandini Chauhan, Nagendra Singh Chauhan,

Ramesh K.Goyal, and Kamal Shah

2. Nanocarriers Systems and Their Application for the Delivery of Different

Phytoconstituents ........................................................................................................................... 9

Ebru Altuntaş, Gülgün Yener, and Burcu Özkan

3. Liposome-Based Nanocarrier System for Phytoconstituents .................................................... 45

Ngoc Thuy Trang Le, Linh Phuong Tran Pham, Diem Huong Tran Nguyen, Ngoc Hoang Le,

Tuong Vi Tran, Cuu Khoa Nguyen, and Dai Hai Nguyen

4. Phytosomes as Novel Carriers of Herbal Extracts ...................................................................... 69

Sevgi Güngör, Özlem Akbal-Dağıstan, Evren Algın Yapar, Murat Kartal, and Yıldız Özsoy

5. Lipid-Based Nanoparticles: SLN, NLC, and MAD .................................................................... 81

Rita Cortesi, Paolo Mariani, Markus Drechsler, and Elisabetta Esposito

Section II Application of Phytodrug Delivery

6. Phytosomes as Useful Drug Delivery Systems for Cosmeceutical Application ...................... 105

Francesca Froiio, Agnese Gagliardi, Massimo Fresta, Donato Cosco, and Donatella Paolino

7. Novel UV Filtering Agents for Next-Generation Cosmetics: From Phytochemicals to

Inorganic Nanomaterials ..............................................................................................................121

Aditya Arya and Jayanti Jha

8. Development of Ethosome Formulation for Topical Therapeutic Applications ..................... 137

Mansoureh Nazari Vishkaei, Mohamed B. Khadeer Ahamed, and Amin Malik Shah

Abdul Majid

9. Application of Phytodrug Delivery in Anticancer Therapy ..................................................... 157

Xiuhua Wang and Shirui Mao

Section III Phytomolecule Drug Delivery

10. Improved Silymarin Characteristics for Clinical Applications by Novel Drug

Delivery Systems ........................................................................................................................... 195

Maryam Tabarzad, Fatemeh Ghorbani-Bidkorbeh, and Tahereh Hosseinabadi

11. Silymarin—A Scintillating Phytoantioxidant: Clinical Applications and Bio-delivery

Problems ........................................................................................................................................ 223

Aditya Arya, Subhojit Paul, and Anamika Gangwar

12. Innovative Delivery Systems for Andrographolide Delivery ................................................... 241

A. C. Santos, J. A. D. Sequeira, F. Veiga, A. Figueiras, and A. J. Ribeiro

13. Polymeric Colloidal Carriers for Natural Polyphenolic Compounds ......................................261

Maria Rosaria Lauro, Teresa Musumeci, Francesca Sansone, Giovanni Puglisi, and

Rosario Pignatello

14. Drug Delivery Systems for the Controlled Delivery of Berberine ........................................... 283

Rosario Pignatello, Simona Cianciolo, and Agata K. Giuffrida

15. Lipid-Based Nanoformulations from Plants for Sustainable Drug Delivery ......................... 301

Ilaria Clemente, Ilaria Colzi, and Sara Falsini

16. Nanotechnological-Based Drug Delivery System for Magical Molecule Curcumin:

Delivery, Possibilities and Challenges .........................................................................................313

Madhu Gupta, Vikas Sharma, Durgesh Nandini Chauhan, Nagendra Singh Chauhan,

Kamal Shah, and Ramesh K. Goyal

Index .......................................................................................................................................................333

Editors

Madhu Gupta has research experience pertaining to drug delivery

to nanoformulations for magical molecule delivery, bioligands for

targeting of bioactives and drug moiety, biopolymers, cancer nanomedicine,

as well as topical delivery that is carried out at the

Department of Pharmaceutical Sciences, Dr. H.S. Gour Central

University, Sagar. Dr. Gupta has done her B. Pharm (Gold Medalist),

M. Pharm, PhD in Pharmaceutics with experience of more than

12 years in academics, administrative functions, and research in

areas of pharmaceutical nanotechnology and targeted drug delivery

related to cancer, fungal infection, and psoriasis.

Presently she is working as an officer on special duty to Vice-

Chancellor in Delhi Pharmaceutical Sciences and Research

University. Along with teaching and research, she is Chief Operating

Officer of World Class Skill Centre courses, PRO, website In-charge,

IQAC in addition to much other managerial work.

She is pioneer scientist in the fields of nanotechnology and drug delivery. She has judiciously exploited

bioligands for targeting of bioactives and drug moiety. She has over 40 research publications to her

credit published in journals of high scientific impact and contributed 18 chapters in various renowned

books and to several international and national books. Dr. Gupta has H-index of 12, i10-index of 14, and

more than 600 citations. She has been awarded by various national and international conferences in the

form of best oral and poster presentation award and other national and international awards. She has

supervised 15 MPharm students. Dr. Gupta has availed several prestigious fellowships and awards

SRF AICTE (NDF), JRF (AICTE), Travel grant awards (DST, ICMR, INSA, and DBT, MPCST), Prof.

G.P. Nair Award (2004), and Prof. C.S. Chauhan Award (2004). She has her research work at BioAsia