Neurosecretion: Secretory Mechanisms, 1st ed. 2020 Masterclass in Neuroendocrinology Series, Vol. 8

How do electrical activity and calcium signals in neurons influence the secretion of peptide hormones? This volume presents the current state of knowledge regarding the electrical, calcium signaling and synaptic properties of neuroendocrine systems from both vertebrate and invertebrate systems. The contributions span in vivo and in vitro studies that address: state?dependent plasticity, relevance of firing patterns, membrane properties, calcium flux (including dynamic imaging and homeostasis), and molecular mechanisms of exocytosis, including from non-neuronal secretory cells. The chapters focus not only on research results but also on how experiments are conducted using state-of-the-art techniques, and how the resulting data are interpreted.

While there are many books on the secretory properties of neurons, this is the first to focus on the distinctive secretory properties of neuroendocrine neurons. Accordingly, it offers an important text for undergraduate and graduate neuroscience students, and will also appeal to established scientists and postdoctoral fellows.

Neurosecretion: A Historical Overview.- Neurosecretion: Hypothalamic Somata versus Neurohypophysial Terminals.- Cyclic ADP-Ribose and Heat Regulate Oxytocin Release via CD38 and TRPM2 in the Hypothalamus.- Somato-Dendritic Secretion of Neuropeptides.- Neurosecretory Vesicles: Structure, Distribution, Release and Breakdown.- Molecular Controls on Regulated Neurotransmitter and Neurohormone Secretion.- Secretory Astrocytes.- Action Potential-Induced Ca2+ Influx for Both Acute and Sustained Insulin Secretion in Pancreatic Beta Cells.- Plasticity in the Morphology of Lactotrophs and Folliculo-Stellate Cells and Prolactin Secretion.- Neuroendocrine and Metabolic Regulation of Plasma Growth Hormone Secretory Profiles.- Role of the TWIK-Related Potassium (TREK)-1 Channels in the Regulation of Adrenocorticotropic Hormone (ACTH) Secretion from Pituitary Corticotropes.- How Do Bacterial Neurotoxins Affect Neurosecretion?.- Secretory Mechanisms in Paramecium.