Neuroblastoma, 1st ed. 2020 Clinical and Surgical Management

This book addresses neuroblastoma, a type of embryonic tumor derived from neural crest cells and one of the most frequent extra-cranial solid tumors in children. However, the term also describes a heterogeneous group of tumors, the prognosis of which can differ greatly according to age, stage and biology. Some forms undergo spontaneous regression, and some are cured by surgery alone or after chemo-reduction, while others exhibit extremely aggressive behavior. Their successful treatment is one of the best examples of tailored medicine, which involves close collaboration between pediatric surgeons, pediatric oncologists, radiologists, nuclear medicine specialists, biologists, oncogeneticists and radiotherapists.   

Chapter 1. Epidemiology.- Chapter 2. Biology of neuroblastoma.- Chapter 3. Neuroblastoma pathogenesis.- Chapter 4. Neuroblastoma Pathology.- Chapter 5. Radiology .- Chapter 6. Image Defined Risk Factors .- Chapter 7. Nuclear Medicine procedures in Neuroblastoma.- Chapter 8. Radiotherapy for neuroblastoma.- Chapter 9. Spinal canal involvement in peripheral neuroblastic tumors.- Chapter 10. Neonatal Neuroblastoma.- Chapter 11. Low and intermediate risk Neuroblastoma.- Chapter 12. High risk Neuroblastoma and current Protocols.- Chapter 13. Immunotherapy.- Chapter 14. Prognostic Factors and Risk Stratification.- Chapter 15. BIOPSY OF NEUROBLASTOMA.- Chapter 16. Surgical Techniques.- Chapter 17. Surgical strategies for high risk neuroblastoma.- Chapter 18. Surgical strategies for Neuroblastoma with spinal canal involvement.- Chapter 19. Neuroblastoma – Minimally invasive surgery.- Chapter 20. Robotic Surgery for Neuroblastoma.- Chapter 21. Complications of the surgical management of children with neuroblastoma.- Chapter 22. Palliative Care.

Sabine Sarnacki (M.D, Ph.D) is a Professor and Head of the Pediatric Surgery Unit at Necker Enfants Malades Hospital in Paris. She has been engaged in pediatric surgical oncology for more than 15 years and is particularly interested in neuroblastoma, neonatal and rare tumors. She has headed the surgical subcommittee of SIOPEN (International Society of Paediatric Oncology European Neuroblastoma) since 2013 . She has extensive experience in transplantation immunology, enteric nervous system development and preservation of fertility. She is the scientific director of the Parisian School of Surgery and involved in the national master of surgical research program. Further, she is the head of the national reference colorectal center “MAREP” (Malformation AnoRectale et Pelvienne) created in 2007 during the first French National Rare Disease Plan, and was nominated by the French Health Ministry to lead the health part of the second French National Rare Disease Plan.

Luca Pio (M.D.) is a Fellow of Pediatric Surgical Oncology at Necker Enfants Malades Hospital in Paris. Since the beginning of his residency at Giannina Gaslini Children’s Hospital in Genoa, he has been involved in the clinical and research aspects of neuroblastoma. He is an executive board member of the surgical subcommittee of SIOPEN, a member of the IPSO (International Society of Paediatric Surgical Oncology) and a member of the EUPSA (European Paediatric Surgeons’ Association). Since 2017 Dr. Luca Pio is the chairman of the GYPSE (Group of Young Pediatric Surgeons of Europe).

Unique book currently available covering all the fields of clinical and surgical management of Neuroblastoma

Special chapters on new surgical techniques (minimally invasive surgery, robotic surgery)

Includes simple illustrations of surgical technique