Neural Stem Cells and Adult Neurogenesis
Auteur : Mobley Arie S.
Neural Stem Cells and Adult Neurogenesis provides graduate students and neuroscientists with a basic understanding of what neural stem cells are and the cell types they produce. This early graduate level reference describes their physiology and potential for medicine and provides students with fundamental stem cell information. An overview of stem cell sources in the human body and a brief mention of relevant diseases provide context for the value of this knowledge. The book also includes chapters on induced pluripotent stem cells (iPSCs), the methods used to obtain them, and a review of the ethical challenges associated with stem cell research.
For each region, the book provides a description of its neurogenic niche, cellular and molecular biology, and information on the neurons? contribution to normal and diseased brain function. The level of information is appropriate for early graduate students, introducing technology and molecular biology in an accessible format.
Section I. Stem Cells1. History and ethics of stem cells 2. Stem cells: From embryos to adults3. The stem cell niche4. Induced pluripotent stem cells
Section II. Adult Neurogenesis – The Hippocampus5. Introduction to adult neurogenesis6. Adult neurogenesis in the hippocampus7. Adult neurogenesis in the subventricular zone 8. Adult neurogenesis in health and disease
Dr. Mobley received her Ph.D. at the University of Utah, Interdepartmental Neuroscience Program. Her thesis project examined the olfactory sensory neurons of the cephalopod, Lolliguncula brevis. In her postdoctoral lab at Yale University she continued to study the olfactory system focusing on activity dependent mechanisms of development. Her research has been published in journals such as J. Neurosci., J. Comp. Neurol., Trends in Neurosci., Neurobiol. Aging and PNAS. Dr. Mobley has received several grants including the Ruth Kirstein National Research Service Award (NRSA) at the graduate level under Dr. Mary T. Lucero and at the postdoctoral level under Dr. Charles Greer. She went on to obtain an NIH Small Grant Program (R03) award that was instrumental in beginning her independent research program at WNEU.
- Provides a basic understanding of what a stem cell is, the different types, and their potential in health and research
- Details adult neurogenesis and its role in behavior, stroke and disease
- Includes walkthrough and technology boxes that illustrate experimental concepts, new approaches and techniques
Date de parution : 03-2019
Ouvrage de 241 p.
15x22.8 cm
Thèmes de Neural Stem Cells and Adult Neurogenesis :
Mots-clés :
5-Bromo-2′-deoxyuridine (BrdU); Adult neurogenesis; Aging; Alzheimer disease; Amyotrophic lateral sclerosis; Asymmetric generative cell division; Autoradiography; Chromatin; Cloning; CXCL12/CXCR4; Dedifferentiation; Delta/Notch; Dentate gyrus; Depression; Development; Differentiate; Embryonic stem cell; Epigenetics; Epilepsy; Exercise; Germ cell; Germline stem cell; Hair follicle stem cell; Hematopoietic stem cell; Hippocampus; Histones; Immature neurons; Induced pluripotent stem cell; Integration; Intestinal stem cell; JAK/STAT; Learning and memory; Long-term potentiation; Multipotent; Neural migration; Neural progenitor cells; Neural progenitors; Neural stem cell; Neural stem cells; Neuroblast; Neurogenic niche; Olfactory bulb; Olfactory bulb interneuron; Parkinson disease; Plasticity; Pluripotent; Pluripotent cell; Primary neurulation; Radial glia cells; Rostral migratory stream; Self-renewal; Somatic; Somatic cell; Somatic cell nuclear transfer; Somatic stem cells; Stem cell; Stem cell Âethics; Stem cell history; Stem cell niche; Stress; Stroke; Subventricular zone; Survival; Symmetric proliferative cell division; Totipotent; Transcription factor; Transdifferentiation; Transit-amplifying cells; Tritiated thymidine; Unipotent; Viral vectors; Wnt/beta catenin; Zygote