Nanotoxicology (2^nd Ed.) Progress toward Nanomedicine, Second Edition

Since the first publication of this book in 2007, the field of nanoscience and nanomedicine continues to grow substantially. This second edition, Nanotoxicology: Progress toward Nanomedicine, enlists internationally recognized experts todocument the continuing development and rationale for the safe design of engineered nanomaterials (ENM). This includes new improved characterization endpoints, screening, and detection methods for in vitro and in vivo toxicity testing. These tools also contribute greatly to nanosafety research applied to nanomedicines.

Topics include

• The impacts of nanotechnology on biomedicine, including functionalization for tissue-specific targeting, the biointeractions of multifunctional nanoparticle-based therapy, and the ability to control specific physicochemical properties of nanoparticles
• The requirements for proper detection, measurement, and assessment both for workplace exposure and in consumer products?with a focus on potential health and safety implications
• Predictive modeling, using quantitative nanostructure activity relationships to predict the pharmacokinetics and biodistribution of nanomaterials in the body
• Specific methodologies, imaging, and techniques to assess nanomaterials from the manufacturing process to nanomedicine applications
• Tools for assessing nanoparticle toxicity and the limitations of detection methods for assessing toxicity in both in vivo and in vitro systems and at the single cell and tissue levels
• Toxicity of nanomaterials to specific organ systems, cell?based targeting to tumors, and other biomedical applications
• The difficulty of conducting risk assessments and the need for addressing knowledge gaps, especially with long-term studies
• A roadmap for future research

The development of nanotechnology-based products must be complemented with appropriate validated methods to assess, monitor, manage, and reduce the potential risks of ENM to human health and the environment. This volume provides a cogent survey of advances in this area by a well-respected and diverse group of international scientists.

Impacts of Nanotechnology on Biomedicine. Introduction to Biomedical Nanotechnology. Impact of Bionanointeractions of Engineered Nanoparticles for Nanomedicine. Rational Approach for the Safe Design of Nanomaterials. Characterization of Manufactured Nanomaterials, Dispersion, and Exposure for Toxicological Testing. Exposure. Workplace Inhalation Exposure to Engineered Nanomaterials: Detection, Measurement, and Assessment. Nanotechnology in Consumer Products: Addressing Potential Health and Safety Implications for Consumers. Modeling. Quantitative Nanostructure–Activity Relationships: From Unstructured Data to Predictive Models for Designing Nanomaterials with Controlled Properties. Pharmacokinetics and Biodistribution of Nanomaterials. Methodologies and Techniques. Advanced Methodologies and Techniques for Assessing Nanomaterial Toxicity: From Manufacturing to Nanomedicine Screening. Detection Methods for the In Vivo Biodistribution of Iron Oxide and Silica Nanoparticles: Effects of Size, Surface Chemistry, and Shape. Quantitative Single-Cell Approaches to Assessing Nanotoxicity in Nanomedicine Systems. Imaging Techniques for Nanoparticles in Skin. Hazards. Safety Implications of Nanomaterial Exposure to Skin. Interspecies Comparisons of Pulmonary Responses to Fine and/or Nanoscale Particulates: Relevance for Humans of Particle-Overload Responses in the Rat Model. Current In Vitro Models for Nanomaterial Testing in Pulmonary Systems. Nanoparticles and the Immune System. Carbon Nanotubes and Cardiovascular Disease. Single- and Multiwalled Carbon Nanotubes Toxicity and Potential Applications in Neuroregeneration. Current In Vitro Models for Nanomaterial Testing: The Reproductive System. Current In Vitro Models for Nanomaterial Testing: Genotoxicity Issues. Cell-Based Targeting of Anticancer Nanomaterials to Tumors. Silver Nanoparticles in Biomedical Applications. Cytotoxicity of Conjugated and Unconjugated Semiconductor and Metal Nanoparticles. Risk Assessment. Issues Related to Risk Assessment of Nanomaterials.Risk Assessment of Engineered Nanomaterials: State of the Art and Roadmap for Future Research. Index.

Nancy A. Monteiro-Riviere is a Regents Distinguished Research Scholar and University Distinguished Professor of toxicology and director of the new Nanotechnology Innovation Center of Kansas State.

C. Lang Tran is the head of toxicology at the Institute of Occupational Medicine, Edinburgh, United Kingdom.