1.Somatic aspects, (i) Pain, a. evidence base for pain, b. clinical assessment and management of pain, (ii) Fatigue, a. evidence base for fatigue, b. clinical assessment and management fatigue.- 2. Cognition, a. Evidence base for cognition, b. Clinical assessment and management of cognition.- 3. Psychiatric and behavioural aspects, (i)depression, a. evidence base for depression, b. clinical assessment and management of depression, (ii) anxiety, a . evidence base for anxiety, b. clinical assessment and management of anxiety, (iii) anger, a. evidence base for anger, b. clinical assessment and management of anger, (iv) psychosis, a. evidence base for psychosis, b. clinical assessment and management of psychosis, (v) pseudobulbar affect, a. evidence base for pseudobulbar affect, b. clinical assessment and management of pseudobulbar affect.- 4. Self and family, Coping by people with MS, (will include adjustment, self-esteem, self-efficacy), a. Evidence base for coping, b. Clinical assessment and support for coping, (ii)Partners of people with MS, a. Evidence base for partners, b. Clinical assessment and support for partners, (iii) Parents with MS and their children, a. Evidence base for parents with MS and their children, b. Clinical assessment and support for parents with MS and their children.