Mosaic of Autoimmunity The Novel Factors of Autoimmune Diseases
Coordonnateurs : Perricone Carlo, Shoenfeld Yehuda
The Mosaic of Autoimmunity: The Novel Factors of Autoimmune Diseases describes the multifactorial origin and diversity of expression of autoimmune diseases in humans. The term implies that different combinations of factors in autoimmunity produce varying and unique clinical pictures in a wide spectrum of autoimmune diseases. Most of the factors involved in autoimmunity can be categorized into four groups: genetic, immune defects, hormonal and environmental factors. In this book, the environmental factors are reviewed, including infectious agents, vaccines as triggers of autoimmunity, smoking and its relationship with rheumatoid arthritis, systemic lupus erythematosus, thyroid disease, multiple sclerosis and inflammatory bowel diseases.
An entirely new syndrome, the autoimmune/inflammatory syndrome induced by adjuvants (ASIA), is also included, along with other diseases that are now recognized as having an autoimmune etiopathogenesis.
Introduction 1. The history of the mosaic of autoimmunity 2. The novel aspects on the mosaic of autoimmunity
Cellular and molecular mechanisms 3. B cells 4. B-reg5. T cells 6. Th17 cells 7. NK cells 8. Dendritic cells 9. Complement 10. Autoantibodies 11. Anti-DSF70 12. Genetic 13. Epigenetic 14. Post-translational modifications 15. Cytokines and chemokines 16. Autophagy 17. Diagnostic: laboratory18. Diagnostic: imaging
The classical factors associated with autoimmunity 19. Hormones20. Microbiota21. Infections: Viruses and bacteria
The novel environmental factors associated with autoimmunity 22. Geo-epidemiology 23. Seasonality 24. UV 25. Vitamin D 26. Vitamin D pregnancy and autoimmunity 27. Smell 28. Breast feeding 29. Vaccines 30. Silicone 31. Diet: spicy food and fatty acids 32. Diet: gluten 33. Psychological stress 34. Coffee 35. Obesity 36. Physical activity 37. Smoke 38. Cannabis 39. Bisphenol 40. Prolactin
Peculiar aspects 41. Cancer42. Paraneoplastic syndromes
Classical autoimmune diseases 43. SLE 44. APS 45. CAPS 46. RA and inflammatory arthritides47. PsA and Spondyloarthropathies48. MS, MG and other neurological disorders 49. Systemic slcerosis 50. Sjogren 51. ASIA syndrome 52. Reproductive failure 53. Accelerated atherosclerosis 54. New autoimmune diseases
Treatment of autoimmune diseases 55. Neuroimmunology 56. Vasculitis 57. Personalized Medicine 58. Biologics and Biosimilars 59. Small molecules 60. Helminthes 61. Novel therapies and IVIg 62. Autoimmune and allergic disease 63. EBV Molecular Diagnosis 64. Statin and myositis 65. Autoimmunity and primary immunodeficiency
Professor Yehuda Shoenfeld is the President of the Center for Autoimmune Diseases (present), incumbent of the Laura Schwarz-Kipp Chair for Research of Autoimmune Diseases in Tel Aviv University (since 2002–Present), Emeritus Professor of the Sackler School of Medicine in Tel Aviv University and teaches medical studies and MSc and PhD students (since 1985). Prof. Shoenfeld has edited a series of textbooks entailing "The Mosaic of Autoimmunity," "Autoantibodies," "Infection and Autoimmunity," and "Diagnostic Criteria of Autoimmune Diseases" (Elsevier Pub.). He has served on 36 editorial boards and is the organizer of more than 25 international congresses on autoimmunity. He is the author of > 2000 peer-reviewed papers reported in the field of autoimmunity and internal medicine. More than 65,000 citations.
- Highlights the concept of the mosaic of autoimmune manifestations
- Includes new visions on unsuspected molecules
- Provides updated knowledge to physicians helping patients with autoimmune diseases
- Presents thorough, up-to-date information on specific diseases, along with clinical applications
Date de parution : 02-2019
Ouvrage de 728 p.
21.4x27.6 cm