Mood Disorders Practical Issues in Diagnosis and Management

Mood Disorders: Practical Issues in Diagnosis and Management provides cutting edge knowledge about the diagnosis and treatment of principal mood disorders, namely major depressive disorder and bipolar disorder. Covering diagnosis, differentiating features, and illness course and trajectories of principal mood disorders, Dr. Ather Muneer provides essential information in a succinct and practical manner, while highlighting significant new findings in the area. This book will help a broad range of mental health professionals better treat the millions of people with mood disorders across the globe.

Table of Contents

Chapter 1: Major Depressive Disorder and Bipolar Disorder

Introduction

Signs and Symptoms

Diagnosis of Mood Disorders

Major Depressive Disorder

Bipolar Disorder

Seasonal Affective Disorder (SAD)

Conclusion

Chapter 2: Major Mood Disorders: Differentiating Features

Introduction

Allostatic Load Model of Mood Disorders

Mood Disorders as Systemic Ailments

Differentiating Features of Unipolar and Bipolar Depression

Affective Ailments as Spectrum Disorders

Psychometric Scales

How to Differentiate Between Unipolar and Bipolar Depression?

Catatonic Symptoms of Mood Disorders

Conclusion

Chapter 3: Cormorbidity in Mood Disorders

Introduction

The Relation Between Mood Disorders and Inflammatory Comorbidity

Mechanisms Linking Immune-Inflammatory Imbalance to GMC in Mood Disorders

Therapeutic Considerations

Conclusion

Chapter 4: Etiology- The Role of Epigenetics

Introduction

The Relationship Between Mood Disorders and Inflammation

The Biological Mechanisms Linking Mood Disorders and Inflammation

Neuronal Plasticity

Childhood Abuse and Mood Disorders

The Link Between Childhood Trauma and Inflammation

Childhood Trauma and Neuronal Plasticity

The Epigenetic Link

Future Directions

Conclusion

Chapter 5: Neurobiology of Mood Disorders- The Circadian Connection

Introduction

Mood Disorders and the Circadian System

The Neurobiology of the Circadian System

Conclusion

Chapter 6: Pathogenesis of Mood Disorders- The Neuroinflammatory Hypothesis

Introduction

Neuroinflammation- The Role of Cytokines

Inflammation, Kynurenines and Mood Disorders

Purported Model of Depression

Oxidative Stress

Conclusion

Chapter 7: Mood Disorders- Staging and Neuroprogression

Introduction

Developmental Trajectory and Clinical Heterogeneity of Mood Disorders

Neuroprogression as the Basis for Staging Mood Disorders

Allostatic Load and Neuroprogression

Biomarkers of Mood Disorders

Staging Models of BD

Staging Model for MDD

Therapeutic Implications of Staging

Limitations of the Staging Models

Conclusion

Chapter 8: The Management of Treatment Resistant Depression- Monoamines and Beyond

Introduction

Switching or Combining 1st Line Antidepressants for TRD

Combining Atypical Antipsychotics with Standard Antidepressants

Voritoxetine in TRD

Targeting Other Pathways in TRD

Conclusion

Chapter 9: Treatment of Bipolar Depression- The Current Perspective

Introduction

Lithium and Anticonvulsants

Atypical Antipsychotics

Conclusion

Chapter 10: Manic Phase of Bipolar Disorder- Treatment Recommendations

Introduction

Diagnosis of Mania

Treatment of Mania

Maintenance Treatment

Conclusion

Chapter 11: Mood Disorders- Non-Pharmacological Treatments

Introduction

Psychoeducation

Cognitive Behavioral Therapy

Interpersonal and Social Rhythm Therapy

Dialectical Behavior Therapy

Mindfulness-Based Cognitive Therapy

Family Therapies

Future Directions in Research on Psychological Treatments

Conclusion

Ather Munner, MD, is assistant professor of psychiatry at the Islamic International Medical College, Riphah International University, Islamabad. He has published papers in numerous journals, and is a member of the Pakistan Psychiatric Society and the European Psychiatric Association.