Medical Immunology, 7th Edition (7^th Ed.)

This seventh edition of Medical Immunology, now in a full-color presentation, continues to provide a succinct clinical review of the human response to infection while being firmly grounded in science. The authors, distinguished and experienced educators, have been able to anticipate readers? conceptual challenges and use illustrations, diagrams, and algorithms throughout to simplify complex concepts. With an emphasis on clinical applications, methodological advances, immunological diseases, and innovative interventions, this tried and true guide navigates readers through state-of-the-sciences technologies and demonstrates their implementation in the day-to-day clinical practice of immunology.

Key Features

• Stresses both the basic scientific concepts and clinical correlations to medical practice.





• Progresses logically from normal immune function to abnormalities and clinical diseases.





• Reviews the diagnosis, pathogenesis, and management of autoimmune diseases in a concise, manageable and visual manner





• Continues to be the only current medically-focused immunology text available





• Provides a succinct review of human response to infection with a focus on diagnostic and clinical immunology

Introduction. Leukocytes and lymphoid tissues: The framework of the immune system. Major histocompatibility complex. Adaptive immune response: Antigens, lymphocytes, and accessory cells. Immunoglobulins: Structure and diversity. Immunoglobulins: Metabolism and biological properties. Genetics of immunoglobulins: Ontogenic, biological, and clinical implications. Antigen-antibody reactions. The complement system in health and disease. Monocyte and lymphocyte membrane markers: Ontogeny and clinical significance. Cell-mediated immunity. Adaptive humoral immunity and immunoprophylaxis. Phagocytic cells and their functions. Anti-infectious innate and adaptive immune responses. Diagnostic applications of immunology. Tolerance and autoimmunity. Organ-specific autoimmune diseases. Systemic lupus erythematosus. Rheumatoid arthritis. Overview of hypersensitivity. IgE-mediated (immediate) hypersensitivity. Immunohematology. Pathogenic role of antigen-antibody complexes. Immune system modulators. Transplantation immunology. Tumor immunology. Lymphocyte and plasma cell malignancies. Diagnosis of immune deficiency diseases. Primary immunodeficiency diseases. AIDS and other acquired immunodeficiencies

Gabriel Virella obtained his MD and PhD degrees at the University of Lisbon, Portugal, in 1967 and 1974. He did post-doctoral studies in Immunology at the Department of Experimental Pathology, University of Birmingham, England (1968-69) and at the National Institute for Medical Research, Mill Hill, London, England (1969-1970). From 1970 to 1975 was a Researcher at the Gulbenkian Institute of Science, Oeiras, Portugal. He moved to the Medical University of South Carolina (MUSC) in 1975, where he is an Emeritus Professor of Immunology and Microbiology. He has published 260 articles in topics related primarily to immunology, with particular emphasis on the involvement of autoimmune phenomena in the pathogenesis of atherosclerosis. He has described original techniques for the isolation and characterization of antigen-antibody complexes, immunoassays for tetanus and diphtheria antibodies, and for the assay of modified LDL and corresponding antibodies. In 1989 he was co-recipient with Drs. Christoph Gisinger and Maria F. Lopes Virella of the Squibb Award of the Austrian Society for Internal Medicine for the work entitled "Metabolic effects of Lipoprotein Immune Complexes in Macrophages". He co-edited a first edition of "Introduction to Medical Immunology" in 1986, and became the single editor of the 3rd edition, in 1993. The 4 ed. (1999) was translated to the Italian. He has now edited the 7th Ed. of Medical Immunology. In addition, he published "NMS Microbiology and Infectious Diseases", 3rd Ed, Williams&Wilkins, 1997; and NMS Q&A Microbiology, Immunology, and Infectious Diseases, Lippincott Williams & Wilkins, 1999. He was Section Editor of Clinical Immunology from 1989 to 2003. During his tenure at the Medical University of South Carolina he received numerous teaching awards from the students, the Health Science Foundation Teaching Excellence Award, MUSC in 1996 and 2006, Governor's Distinguished Professor Award in 1996 and 2006, the National Robert J.