Mechanisms of Disease Pathogenesis in Multiple Sclerosis

Mechanisms of Disease Pathogenesis in Multiple Sclerosis summarizes our current understanding on MS and its clinical features and monitoring with available biomarkers, focusing on mechanisms that drive disease pathogenesis and their control by genetic, environmental factors and novel therapies for disease management. The book is written for neurologists, neuroimmunologists and clinical, translational and basic researchers interested in mechanisms of neurodegeneration. Multiple Sclerosis (MS) is an autoimmune disease which targets the central nervous system (CNS). It is the most common cause of non-traumatic neurological disability in young adults with a prevalence of 1 in 1000 and increasing, hence the importance of this book.

1. Multiple Sclerosis, clinical course, open questions and unmet clinical needs
2. Novel Imaging Approaches in Multiple Sclerosis
3. Effect of infections on Multiple Sclerosis
4. T cells in Multiple Sclerosis.
5. B cells in Multiple Sclerosis.
6. Microglia in Multiple Sclerosis.
7. Monocytes in Multiple Sclerosis
8. Antigen Presenting Cells in Multiple Sclerosis.
9. Oligodendrocytes in Multiple Sclerosis.
10. Astrocytes in Multiple Sclerosis.
11. The Blood Brain Barrier in Multiple Sclerosis
12. Microbiome in Multiple Sclerosis.

Francisco J. Quintana, PhD, is an Associate Professor of Neurology at the Center for Neurologic Diseases, at Brigham and Women’s Hospital, Harvard Medical School, and an Associate Member at the Broad Institute of Harvard and MIT. Dr. Quintana’s research investigates signaling pathways that control the immune response and neurodegeneration, with the ultimate goal of identifying novel therapeutic targets and biomarkers for immune-mediated disorders. Dr. Quintana has published over 140 peer reviewed articles and book chapters. He is the recipient of the Lady Anne Chain Prize for Academic Excellence and Scientific Achievements, the Junior Investigator Award from the National Multiple Sclerosis Society, the Pathway to Independence Award of the National Institute of Allergy and Infectious Diseases, the Award for Outstanding Research Achievement form Nature Biotechnology and the Tecan Award for Innovation, the Harry Weaver Award from the National Multiple Sclerosis Society, the Young Mentor Award from Harvard Medical School and the Milestones in MS research from the National MS Society.