Management of Hemostasis and Coagulopathies for Surgical and Critically Ill Patients An Evidence-Based Approach

Management of Hemostasis and Coagulopathies for Surgical and Critically Ill Patients: An Evidence-Based Approach offers a concise guide to a sub-specialty of transfusion medicine from the clinical laboratory perspective. It focuses on the clinical tests that may be done during preoperative assessment, intraoperative, and postoperative assessment and management of surgical or critically ill patients. Management of hemostasis and coagulopathies is approached from an evidence-based perspective?the coagulation status of a patient according to the laboratory test results. Algorithms and decision-support software, designed by the authors, guide clinicians with an additional tool to base transfusion dosage on specific laboratory results, including the use of an artificial neural network for predicting more accurate blood use.

Chapters reflect the experience of all three authors who have successfully applied the algorithm for better patient management as well as decreased wastage of expensive blood products, from both the clinical laboratory/pathology and clinical medicine perspective. This book will appeal to a broad section of clinical laboratory and medical practitioners from hematopathology, to internal medicine, surgery, and anesthesiology. For hematopathologists and pathologists who are involved in laboratory medicine and transfusion medicine, this book will help them understand the proper utilization of blood products and how to avoid unnecessary waste and costs for the hospital. For general surgery practitioners, this book will provide practical guidelines on how to use blood products rationally for best medical practice. Internists will also gain insight from this book, learning which patients are at higher risk of bleeding during surgery so that they can alert their clinical colleagues.

1. Coagulation based tests and their interpretation2. Blood bank testing and blood products3. Pharmacotherapy with Antiplatelet, Anticoagulant and their Reversing Agents4. Antiplatelets and anticoagulants5. Pre-operative assessment of patients6. Intraoperative and Postoperative Assessment and Management of Coagulopathy7. Specific clinical situations8. Decision-Support Software for Coagulopathy

Amitava Dasgupta received his Ph. D in chemistry from Stanford University and completed his fellowship training in Clinical Chemistry from the Department of Laboratory Medicine at the University of Washington School of Medicine at Seattle. He is board certified in both Toxicology and Clinical Chemistry by the American Board of Clinical Chemistry. Currently, he is a tenured Full Professor of Pathology and Laboratory Medicine at the University of Kansas Medical Center and Director of Clinical Laboratories at the University of Kansas Hospital. Prior to this appointment he was a tenured Professor of Pathology and Laboratory Medicine at the University of Texas McGovern medical School from February 1998 to April 2022. He has 252 papers to his credit. He is in the editorial board of four journals including Therapeutic Drug Monitoring, Clinica Chimica Acta, Archives of Pathology and Laboratory Medicine, and Journal of Clinical Laboratory Analysis.

• Focuses on the clinical tests that may be done during preoperative assessment, intraoperative, and postoperative assessment and management
• Explains new decision-support software developed by the authors as a tool for the management of bleeding patients
• Reviews common coagulation based tests (indication and interpretation) that are used to assist in the management of bleeding patients
• Provides an overview of various blood products, pharmacotherapeutic agents, antiplatelets, and anticoagulants, their usage strategy, indications, and therapy goals