Leukemia Stem Cells in Hematologic Malignancies, 1st ed. 2019 Advances in Experimental Medicine and Biology Series, Vol. 1143

This book introduces readers to the biology of leukemia stem cells (LSCs) and emphasizes the necessity and importance of targeting LSCs in the treatment of hematopoietic malignancies. It addresses the role of leukemia stem cells in different leukemia diseases and molecular signatures, as well as the metabolic and epigenetic regulation of leukemia stem cell function. With regard to solid tumors, a significant number of blood cancers are believed to be derived from leukemia stem cells (LSCs), which are responsible for disease progression, relapse and drug resistance. Consequently, new therapeutic strategies need to be developed by focusing on the complete eradication of LSCs. Given its scope, the book offers a valuable asset for graduate students and scientists in the fields of cell biology and cancer research etc.

Role of leukemia stem cells in pathogenesis of hematologic malignancies.- Leukemia stem cells in chronic myeloid leukemia.- Leukmeia stem cells in MLL-rearranged acute myeloid leukemia.- Interaction between leukmeia stem cells and bone marrow environment.- Molecular signatures of leukemia stem cells.- Metabolic regulation of leukemia stem cell function.- Epigenetic regulation of leukmeia stem cell function.- DNA instability and leukemia stem cell function.- Tumor suppressor genes in leukemia stem cells.- Targeting leukemia stem cells.- Leukemia stem cells and drug resistance.- Hypoxia and leukemia.