Immunology of Endometriosis Pathogenesis and Management Reproductive Immunology Series

Immunology of Endometriosis: Etiology and Management, a volume in the Reproductive Immunology series, provides updates on one of most common gynecological diseases, including basic science concepts and their clinical applications related to endometriosis immunology. Various immunological factors are believed to play roles in the pathogenesis of endometriosis, providing potential targets for the disease. Endometriosis is now considered to be a disease of both endocrine and immune dysregulation. However, recognition of the direct involvement of two major physiological mechanisms brings about a change of focus which might represent an interesting advance in the understanding of this disease and new focus for further research.

1. B lymphocytes
L.G.C. Riccio and M.S. Abrão
2. Macrophages in endometriosis: they came, they saw, they conquered
Kavita Panir, Mary Louise Hull, and Erin Greaves
3. Dendritic cells
Gentaro Izumi
4. Immune factors in the pathogenesis and the potential therapeutic target of endometriosis 1e4 neutrophils
Masashi Takamura
5. Role of Th1, Th2, Th17, and regulatory T cells in endometriosis
Khaleque N. Khan, Akira Fujishita, Yukiko Tanaka, and Jo Kitawaki
6. Auto-immunity and endometriosis: evidence, mechanism and therapeutic potential
Tao Zhang, Tin-Chiu Li, and Chi-Chiu Wang
7. Role of estrogen and estrogen-related factors in endometriosis
Taisuke Mori and Jo Kitawaki
8. Immune factors in the pathogenesis and the potential therapeutic target of endometriosis
Wan-Ning Li, Meng Hsing Wu, and Shaw-Jenq Tsai
9. The roles and functions of macrophages in endometriosis
Miaomiao Ji, Xue Jiao, Sun-Wei Guo, and Guoyun Wang
10. The role of immune factors in endometriosis-related conditions, 2-1 pain
Fabio Barra, Giulio Evangelisti, Carolina Scala, and Simone Ferrero
11. Immune phenotypes and mediators affecting endometrial function in women with endometriosis
Linda C. Giudice and Julia Vallve Juanico
12. The role of immune factors in endometriosis-related conditions, 2e3 ovarian dysfunction
Michio Kitajima
13. The role of immune-related redox biology in malignant transformation of endometriosis
Hiroshi Kobayashi
14. Pregnancy complications
Louis Marcellin, Pietro Santulli, and Charles Chapron
15. Prevalent innate and adaptive immune mechanisms in endometriosis
Ryan M. Marks, Harshavardhan Lingegowda, Alison McCallion, Anushka Nair, and Chandrakant Tayade
16. Novel therapeutic strategy: antiinflammatory reagents
Hiroaki Komatsu, Fuminori Taniguchi, and Tasuku Harada
17. Gut microbiota and endometriosis
Osamu Yoshino, Yosuke Ono, and Takehiro Hiraoka
18. Immunosuppression and immunotherapy in endometriosis: review of pathophysiology, recent development and future perspectives
Ying He, Kennes Sze Wan Hung, Hui Xu, and Chi Chiu Wang
19. Novel diagnostic strategies for endometriosis
Mathew Leonardi, Jodie Avery, and M. Louise Hull

Kaori Koga, M.D., Ph.D. is a physician-scientist and an Associate Professor of the Department of Obstetrics and Gynecology, School of Medicine at the University of Tokyo, Japan. Dr. Koga received her M.D. degree from Chiba University, Chiba, Japan, and her Ph.D. degree from the University of Tokyo. She undertook post-doctoral fellowships in the Uterine Biology Group (Prof. Lois Salamonsen’s laboratory) at Prince Henry’s Institute, Melbourne, Australia in 2006, and the Reproductive Immunology Unit (Prof. Gil Mor’s laboratory) at the Department of Obstetrics, Gynecology and Reproductive Sciences in Yale University in 2006–2008. Dr. Koga's keen interest lies in Reproductive Immunology, with particular focus on endometriosis and infertility. As a gynecological clinician, Dr. Koga has treated many patients with endometriosis and has performed Minimally Invasive Surgery and Aassisted Reproductive Technology. Dr. Koga has received numerous national and international awards, including Kanzawa Award from the Kanzawa Medical Research Foundation in 2018 and Guston Award from the American Society for Reproductive Immunology (ASRI) in 2008. She is a member of the ASRI, the International Society for Immunology of Reproduction (ISIR) as well as of the European Society of Human Reproduction and Embryology (ESHRE), and an ambassador of the World Endometriosis Society (WES). Dr Koga is an Associate Editor of Human Reproduction Open (2021–) and serves on the editorial boards of the American Journal of Reproductive Immunology, and the Journal of Reproductive Immunology.