Part A. Causes, Biological and Molecular bases of HCC
Chapter 1. Epidemiology of Hepatocellular Carcinoma - Donna L. White, Fasiha Kanwal, Li Jiao and Hashem B. El-Serag
Chapter 2. Environmental Carcinogens and Risk for Human Liver Cancer - John D. Groopman
Chapter 3. Molecular Mechanisms of Hepatocellular Carcinoma - Hani Alotaibi, Nese Atabey, Kasım Diril, Esra Erdal and Mehmet Ozturk
Chapter 4. Chemically-Induced Hepatocarcinogenesis - Yvonne P. Dragan
Chapter 5. Molecular Profiling of Human Hepatocellular Carcinoma - Anuradha Budhu and Xin Wei Wang
Chapter 6. Genomic signatures of risk factors and molecular identification of HCC subtypes - Jean-Charles Nault and Jessica Zucman-Rossi
Chapter 7. MicroRNAs and hepatocellular carcinoma - Aldo Cavallini
Chapter 8. Non-tumor prognostic factors in hepatocellular carcinoma - Nicolas Goossens, Ismail Labgaa and Augusto Villanueva
Chapter 9. Gut microbiota and HCC - Sven H. Loosen, Christoph Roderburg and Tom Luedde
Chapter 10. Hepatocellular Carcinoma as a Paradigm for a Systemic Evolutionary Approach to Cancer - Antonio Mazzocca, Giovanni Ferraro, Giovanni Misciagna and Brian I. Carr
Chapter 11. HCC and its Microenvironment - Brian I. Carr
Chapter 12. Circulating tumor cells (Liquid Tumor Biopsy) in hepatocellular carcinoma: biology, methodologies, and clinical implications - Zhengfen Yin
Chapter 13. Role of the immune system in hepatocellular carcinoma: Implications for existing and novel therapies - Tobias Flecken and Robert Thimme
Chapter 14. Inter- and Intratumor Heterogeneity in Hepatocellular Carcinoma - Evgeny V. Denisov, Tatiana S. Gerashchenko, Marina V. Zavyalova, Vasiliy N. Manskikh, Evgeny L. Choinzonov, Nadezhda V. Cherdyntseva and Vladimir M. Perelmuter
Chapter 15. Systemic inflammation: a new prognostic domain and source of therapeutic targets in hepatocellular carcinoma - David J. Pinato and Rohini Sharma
Chapter 16. Hepatocellular Carcinoma Associated with Hepatitis B virus - Inbal Houri and Oren Shibolet
Chapter 18. Obesity, NASH and HCC - Chadia L. Robertson, Devanand Sarkar and Arun J. Sanyal
Chapter 19. Metabolic Disease and Hepatocellular Carcinoma - David H. Van Thiel, Salamah Mohammad Alwahsh and Giuliano Ramadori
Part B. Diagnosis
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Chapter 20. Pathologic Aspects of Hepatocellular Tumors - Michael A. Nalesnik
Chapter 21. Protein biomarkers in the management of hepatocellular carcinoma: Novel combinatory approaches - Philip Johnson and Sarah Berhane
Chapter 22. Surveillance for hepatocellular carcinoma - Cristina Della Corte and Massimo Colombo
Chapter 23. Use of Imaging Techniques to Screen for Hepatocellular Carcinoma - Satoshi Goshima
Chapter 24. Ultrasound of Hepatocellular Carcinoma: The Important Contribution of Contrast Enhancement - Tae Kyoung Kim, Hyun-Jung Jang and Stephanie R. Wilson
Chapter 25. MRI for Detection and Evaluation of Hepatocellular Carcinoma - Anuj Patel, Neil Malhotra, Christopher G. Roth, Sandeep Deshmukh and Donald G. Mitchell
Chapter 26. Computed Tomography of HCC - Francesco Agnello and Giuseppe Brancatelli
Chapter 27. Clinical features and clinician's diagnostic approach to hepatocellular carcinoma - Tamar Thurm and Oren Shibolet
Chapter 28. Current HCC Staging systems: their uses and limitations - Yukio Tokumitsu and Hiroaki Nagano
Part C. Therapies
Chapter 29. Percutaneous Ethanol Injection - Tito Livraghi, Maria Franca Meloni and Anita Andreano
Chapter 30. Thermal Ablative Treatments For Hepatocellular Carcinoma - Antonio Facciorusso and Michele Barone
Chapter 31. Resection of Hepatocellular Carcinoma - Nir Lubezky, Yaacov Goykhman, Richard Nakache and Ido Nachmany
Chapter 32. Liver Transplantation for Hepatocellular Carcinoma - Georg Györi, Pierre-Alain Clavien and Mickaël Lesurtel
Chapter 33. Medical Therapy of HCC - Brian I. Carr, Srikanth Nagalla and Ravit Geva
Chapter 34. Targeted therapies for Hepatocellular Carcinoma - Susan Kralian and Brian I. Carr
Chapter 35. Radiation Therapy for Hepatocellular Carcinoma - Andrew S. Kennedy
Chapter 36. Psychosocial Issues in Hepatocellular carcinoma - Jennifer L. Steel, Feridey N. Carr, Alexandra Savkova, Naadia Ahmed, Andrea DiMartini and Mary A. Dew
Chapter 37. Bringing it all together - Brian I. Carr