Heat Shock Proteins in Cancer, Softcover reprint of hardcover 1st ed. 2007 Heat Shock Proteins Series, Vol. 2
Coordonnateurs : Calderwood Stuart K., Sherman Michael Y., Ciocca Daniel R.
Heat shock proteins are emerging as important molecules in the development of cancer and as key targets in cancer therapy. These proteins enhance the growth of cancer cells and protect tumors from treatments such as drugs or surgery. However, new drugs have recently been developed particularly those targeting heat shock protein 90. As heat shock protein 90 functions to stabilize many of the oncogenes and growth promoting proteins in cancer cells, such drugs have broad specificity in many types of cancer cell and offer the possibility of evading the development of resistance through point mutation or use of compensatory pathways. Heat shock proteins have a further property that makes them tempting targets in cancer immunotherapy. These proteins have the ability to induce an inflammatory response when released in tumors and to carry tumor antigens to antigen presenting cells. They have thus become important components of anticancer vaccines. Overall, heat shock proteins are important new targets in molecular cancer therapy and can be approached in a number of contrasting approaches to therapy.
First book to comprehensively cover heat shock proteins in cancer -- an area of high interest
Detailed discussion of the role of hsp90 in cancer therapy and drug development
Heat shock proteins both as targets for chemotherapy and immunotherapy are examined
Unique mechanisms for Hsp in cancer such as apoptosis, senescence and a role in NDA repair are discussed
Date de parution : 11-2010
Ouvrage de 400 p.
15.5x23.5 cm
Disponible chez l'éditeur (délai d'approvisionnement : 15 jours).
Prix indicatif 210,99 €
Ajouter au panierDate de parution : 09-2007
Ouvrage de 400 p.
15.5x23.5 cm
Thèmes de Heat Shock Proteins in Cancer :
Mots-clés :
Anti-cancer vaccine; Antigen; Cancer therapy; Heat shock proteins; apoptosis; regulation; senescence; surgery