Handbook of Focal Therapy for Prostate and Renal Cancer

Prostate cancer is the commonest cancer in men. Current treatments include surgery to remove the whole prostate or radiotherapy of the whole prostate. These radical treatments can treat the cancer effectively but often cause unwanted side effects.

Meanwhile widespread screening with prostate-specific antigen has led to an increased diagnosis of localised prostate cancer; at the same time, widespread use of abdominal imaging has led to increased detection of renal masses. In response to demand for improved outcomes with reduced side effects, focal therapy has emerged as an important procedure in managing both prostate and renal cancers. It targets individual areas of cancer, reducing unwanted side effects and the amount of damage to collateral tissue. This new method of treatment has major advantages: it involves less radiation, the removal of less tissue and less time spent in hospital.

Handbook of Focal Therapy for Prostate and Renal Cancer provides a comprehensive, timely review of targeted ablation methods to treat prostate and renal cancers. It describes the most effective techniques in current practice, with discussion of the selection criteria, ablation technologies and their limitations, and advice on the management of common side effects. The book opens with a summary of the principles of prostate and renal cancer treatment and the mechanisms of focal therapy. Separate sections on prostate and kidney follow, covering the role of focal therapy, side effects and their treatment and follow-up after targeted ablation.

Written in a practical, clinically-oriented style, Handbook of Focal Therapy for Prostate and Renal Cancer is the ideal reference for urologists, radiologists and radiation oncologists wishing to employ the latest focal therapy techniques in the care of their patients.

SECTION 1: RATIONALE FOR FOCAL TREATMENT OF PROSTATE AND RENAL CANCER

Rationale for focal treatment

• Chapter 1 - The evolution from whole gland to focal treatment in contemporary oncology
• Chapter 2 - Mechanisms for cell death in ablative technologies
• Chapter 3 - How can focal treatment become recognized as a true alternative in prostate and renal cancer treatment?

Rationale for focal treatment of prostate cancer

• Chapter 4 - Health-related quality of life implications of primary whole gland treatment of prostate cancer
• Chapter 5 - Salvage radical prostatectomy for recurrence of prostate cancer after radiation treatment
• Chapter 6 - Clinical utilization of novel biomarkers in the diagnostic and treatment paradigm and follow-up of prostate cancer

Rationale for focal treatment of renal cancer

• Chapter 7 - From incidentaloma to renal cancer
• Chapter 8 - The need for better anatomical and histological characterization of small renal tumors before ablative therapy
• Chapter 9 - Every nephron counts: how to ensure optimal long-term renal function after treatment for renal cancer

SECTION 2: PRACTICAL FOCAL TREATMENT OF PROSTATE CANCER

Before treatment

• Chapter 10 - The role of TRUS-guided prostate biopsy in focal treatment of prostate cancer
• Chapter 11 - The role of MRI and image fusion-guided biopsies in focal treatment of prostate cancer
• Chapter 12 - Patient selection for focal treatment of prostate cancer

Internally delivered energies

• Chapter 13 - Cryosurgical ablation of prostate cancer
• Chapter 14 - Focal laser ablation of prostate cancer
• Chapter 15 - Vascular targeted photodynamic treatment for prostate cancer
• Chapter 16 - Emerging technologies for focal ablation of prostate cancer: irreversible electroporation (IRE), laser ablation, and vapor technology

Externally delivered energies

• Chapter 17 - High intensity focused ultrasound (HIFU) treatment of prostate cancer
• Chapter 18 - External radiation as a focal treatment of prostate cancer

After treatment

• Chapter 19 - Side effects of focal treatment of prostate cancer
• Chapter 20 - Focal ablation as salvage treatment of prostate cancer
• Chapter 21 - Follow-up after focal treatment of prostate cancer

SECTION 3: PRACTICAL FOCAL TREATMENT OF RENAL CANCER

Before treatment

• Chapter 22 - Patient selection for focal treatment of renal cancer

Surgical extirpation

• Chapter 23 - Surgical extirpation of renal cancer

Laparoscopic guided ablation

• Chapter 24 - Laparoscopic-guided cryoablation and radio frequency ablation of renal cancer

Percutaneous guided ablation

• Chapter 25 - Percutaneous image-guided radiofrequency ablation and cryoablation of renal cell carcinoma
• Chapter 26 - Emerging technologies for focal ablation of renal cancer

After treatment

• Chapter 27 - Side effects of focal extirpation and ablation of renal cancer
• Chapter 28 - Salvage treatment of renal cancer after primary focal ablation failure
• Chapter 29 - Follow-up imaging after focal treatment of renal cancer

Truls Bjerklund Johansen, MD DMSci
Professor of Urology, University of Oslo, Norway; Adj. Ass. Prof of Experimental Urological Surgery, University of Aarhus, Denmark; Consultant Urological Surgeon, Oslo University Hospital, Norway

Damian Greene, MCh FRCS (Urol) DG
Consultant Urological Surgeon and Visiting Professor, Sunderland Royal University Hospital, Sunderland, UK

David J. Breen, MRCP, FRCR
Consultant Abdominal Radiologist, University Hospital of Southampton, Southampton, UK

Vladimir Mouraviev, MD, PhD
Director of Clinical Research, Associated Medical Professionals of New York, Syracuse, NY, USA