Handbook of Dystonia (2^nd Ed.) Neurological Disease and Therapy Series

As many as 250,000 people in the United States have dystonia, making it the third most common movement disorder following essential tremor and Parkinson's disease.

Authoritative and reader-friendly, Handbook of Dystonia, Second Edition provides a wide-ranging overview of the latest research and developments regarding the pathogenesis, evaluation, and management of the disease. The book offers detailed coverage of every available treatment option for dystonia and includes four categorized sections on medical management, botulinum toxin injections, phenol and neurolytic therapy, and surgical intervention.

The book reviews the genetic factors of dystonia and supplies in-depth coverage of the neuroanatomy, neurophysiology, and neuropathology of the disease. It covers secondary causes of dystonia, including drug-induced and psychogenic presentations. It also examines non-motor symptoms relating to movement disorders and analyzes innovative approaches for treatment including deep brain stimulation.

New to the Second Edition:

• Four new chapters dedicated to the discussion of individual botulinum toxins recently approved to treat dystonia: Botox, Myobloc, Disport, and Xeomin
• Dystonic symptoms associated with Parkinson?s disorders
• The use of Transcranial Magnetic Stimulation (TMS) as a treatment option for dystonia
• Spasticity and its pathogenesis, evaluation, and treatment with toxins, other injectables and surgical therapies

Summarizing what is known about the disorder, the book dramatically improves the recognition and understanding of this debilitating disease.

SECTION I: EPIDEMIOLOGY AND PATHOGENESIS: Introduction to Dystonia. Epidemiology Dystonia. Genetic Evaluation in Hereditary Dystonia . Functional Anatomy of the Basal Ganglia . Physiology of Primary Dystonia. Pathology of the Dystonias. Neuroimaging in Dystonia. SECTION II: SIGNS AND SYMPTOMS: Primary Generalized Dystonia. Cranial Dystonia. Cervical Dystonia. Limb Dystonia. Spasmodic Dysphonia. Embouchure and Other Task-Specific Musician’s Dystonias. Sports-Related Task-Specific Dystonia: The Yips. Dopa-Responsive Dystonia. Rapid Onset Dystonia-Parkinson. Secondary Dystonia. Dystonic Symptoms Associated with Parkinsonian Disorder. Drug-Induced Dystonia. Psychogenic Dystonia. Nonmotor Symptoms in Dystonia. Spasticity. SECTION III: TREATMENT OPTIONS: Medical Therapy for Dystonia. Anatomic Principles for Botulinum Toxin Injection. Botulinum Toxin: From Molecule to Clinic. Botulinum Toxins in the Treatment of Dystonia. Botox onabotulinumtoxinA. Myobloc rimabotulinumtoxinB. Dysport abobotulinumtoxinA. Xeomin incobotulinumtoxinA. Peripheral neurolysis in the treatment if dystonia. Selective Denervation in Cervical Dystonia. Repetitive transcranial Magnetic Stimulation in the Treatment for Dystonia. Brain Surgery for Dystonia.

Mark A. Stacy, Duke University Medical Center, North Carolina, USA

Handbook of Dystonia, Second Edition, will again be edited by Mark A. Stacy, whose reputation in the industry as an expert in this movement disorder has only grown since he developed the very successful first edition. Dr. Stacy, now a professor of neurology at Duke University, has attracted a team of internationally-recognised movement disorder specialists to write the first edition of the book. These experts have returned to update their chapters, and new treatment specialists have been recruited to write the new botulinum toxin chapters.