Genes, Brain Function, and Behavior What Genes Do, How They Malfunction, and Ways to Repair Damage

Langue : Anglais

Auteur : Wahlsten Douglas

Couverture de l’ouvrage Genes, Brain Function, and Behavior

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Genes, Brain Function, and Behavior offers a concise description of the nervous system that processes sensory input and initiates motor movements. It reviews how behaviors are defined and measured, and how experts decide when a behavior is perturbed and in need of treatment. Behavioral disorders that are clearly related to a defect in a specific gene are reviewed, and the challenges of understanding complex traits such as intelligence, autism and schizophrenia that involve numerous genes and environmental factors are explored. New methods of altering genes offer hope for treating or even preventing difficulties that arise in our genes. This book explains what genes are, what they do in the nervous system, and how this impacts both brain function and behavior.

1. Levels of explanation2. Genes3. Gene expression4. Nervous system5. Brain development6. Behavior7. Single gene transmission and expression8. Phenylketonuria – recessive expression9. Huntington disease – dominant expression10. Androgen insensitivity syndrome – X-linked transmission 11. Leber’s optic neuritis – mitochondrial transmission12. Down syndrome – trisomy 2113. XYY male14. Complex traits15. Intelligence16. Autism spectrum disorder17. Schizophrenia18. Sex and gender19. Race20. Applications and ethics; dignity and human rights

Neuroscientists, neurobiologists, neuro-oncologists, neurologists, post-doctoral fellows, researchers, graduate students in biological and biomedical sciences

Dr. Wahlsten received his Ph.D. degree in psychology from the University of California Irvine and completed his postdoctoral work in behavior genetics at the Institute for Behavioral Genetics at the University of Colorado. He then established research laboratories at the University of Waterloo, the University of Alberta, and the University of North Carolina. The laboratory work involved genetic and developmental analysis of mouse brain defects and methods of behavioral testing. He also acquired expertise in statistical data analysis and theoretical issues central to the field. He was a co-founder of the very successful journal Genes, Brain and Behavior, and was given the Distinguished Scientist award by the International Behavioral and Neural Genetics Society. Throughout his career, he has taught behavioral and neural genetics to undergraduate and graduate students.

Presents essential background, facts, and terminology about genes, brain function, and behavior
Builds clear explanations on this solid foundation while minimizing technical jargon
Explores in depth several single-gene and chromosomal neurological disorders
Derives lessons from these clear examples and highlights key lessons in boxes
Examines the intricacies of complex traits that involve multiple genetic and environmental factors by applying lessons from simpler disorders
Explains diagnosis and definition
Includes a companion website with Powerpoint slides and images for each chapter for instructors and links to resources